{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:47:35Z","timestamp":1772466455364,"version":"3.50.1"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Helminth infection is highly prevalent in indigenous chickens reared in semi-scavenging\/ scavenging systems in Bangladesh. Here, we estimated the prevalence of gizzard worm infection in indigenous chickens, the detection of the worm-induced pathologies, the development of <jats:italic>ex vivo<\/jats:italic> cultural protocol, and anthelmintic efficacy. We randomly collected and examined 390 chickens and isolated worms from the gizzard and proventriculus. The isolated worms were identified as <jats:italic>Cheilospirura hamulosa<\/jats:italic> Diesing, 1861. The overall prevalence of <jats:italic>C. hamulosa<\/jats:italic> was 33.1% (129 out of 390). Prevalence of the worm was almost similar in both sexes but significantly (p\u00a0&lt;0.05) higher in adult chickens (44.3%) and in the summer season (47.1%). In heavy infections, <jats:italic>C. hamulosa<\/jats:italic> destroyed the muscular layer of the gizzard. The presence of brown necrotic tissues and curd-like caseous materials was detected in the affected gizzards. In severe cases, the horny lining of the gizzard was inflamed, necrotized and marked by multiple holes and brick-red colored spots. Liquefied, fetid materials oozed out from the muscular layer in extensive cases. Histopathological examination showed marked infiltrations of eosinophils. In serum-supplemented M199 and DMEM, adult <jats:italic>C. hamulosa<\/jats:italic> survived well and reproduced. Levamisole (LEV) and ivermectin (IVM) efficiently killed the worm. However, albendazole (ABZ), mebendazole (MBZ) and piperazine (PPZ) did not kill the worms. Our results suggest that <jats:italic>C. hamulosa<\/jats:italic> is highly prevalent in semi-scavenging chickens in Bangladesh. LEV and IVM can be used to treat and control the infection in chickens.<\/jats:p>","DOI":"10.1017\/s0031182025000319","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T08:14:26Z","timestamp":1743063266000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["<i>Cheilospirura hamulosa<\/i> (Nematoda: Acuariidae) infection in indigenous chickens in Bangladesh: epidemiology, pathology and anthelmintic efficacy"],"prefix":"10.1017","volume":"152","author":[{"given":"Akter","family":"Shirin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusrat","family":"Nadia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-1036","authenticated-orcid":false,"given":"Md. Shahadat","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmin Shahid","family":"Labony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumaya Naznin","family":"Ritu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Haydar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umme Razia","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romana","family":"Parvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadia Afroz","family":"Esha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita Rani","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8040-2103","authenticated-orcid":false,"given":"Md. Mahmudul","family":"Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Zahangir","family":"Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Abdul","family":"Alim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7350-3093","authenticated-orcid":false,"family":"Anisuzzaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"S0031182025000319_ref6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/bs.apar.2023.02.001","article-title":"Food- and vector-borne parasitic zoonoses: Global burden and impacts","volume":"120","author":"Anisuzzaman","year":"2023","journal-title":"Advances in Parasitology"},{"key":"S0031182025000319_ref11","doi-asserted-by":"crossref","first-page":"e0010513","DOI":"10.1371\/journal.pntd.0010513","article-title":"Correction: A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug 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Bangladesh","volume":"12","author":"Alam","year":"2014","journal-title":"Bangladesh Journal of Veterinary Medicine"},{"key":"S0031182025000319_ref31","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X24000142"},{"key":"S0031182025000319_ref14","doi-asserted-by":"crossref","first-page":"101682","DOI":"10.1016\/j.psj.2021.101682","article-title":"Research note: Genetic analysis, pathology, and vectors of echinostomiasis, a zoonotic helminth infection in chickens in Bangladesh","volume":"101","author":"Labony","year":"2022","journal-title":"Poultry Science"},{"key":"S0031182025000319_ref26","doi-asserted-by":"publisher","DOI":"10.1645\/GE-2255.1"},{"key":"S0031182025000319_ref17","doi-asserted-by":"crossref","first-page":"100162","DOI":"10.1016\/j.crphar.2023.100162","article-title":"Present status with impacts and roles of miRNA on Soil transmitted Helminthiosis control: A review","volume":"5","author":"Mitra","year":"2023","journal-title":"Current Research in Pharmacology and Drug Discovery"},{"key":"S0031182025000319_ref28","unstructured":"Shamim, M (2024) Livestock Economy at a Glance. https:\/\/file-rajshahi.portal.gov.bd\/uploads\/0f236d9d-0a28-4fbd-b4d5-593734ed5892\/670\/9be\/f6e\/6709bef6e805f380007609.pdf (accessed Nov 24 2024 )."},{"key":"S0031182025000319_ref32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011835"},{"key":"S0031182025000319_ref20","doi-asserted-by":"crossref","first-page":"2604685","DOI":"10.1155\/2016\/2604685","article-title":"Importance of indigenous breeds of chicken for rural economy and their improvements for higher production performance","volume":"2016","author":"Padhi","year":"2016","journal-title":"Scientifica"},{"key":"S0031182025000319_ref3","doi-asserted-by":"crossref","first-page":"e13039","DOI":"10.1111\/pim.13039","article-title":"Receptor for advanced glycation end product (rage) modulates inflammation during feeding of the Hard tick, haemaphysalis longicornis in mice","volume":"46","author":"Anisuzzaman","year":"2024","journal-title":"Parasite Immunology"},{"key":"S0031182025000319_ref15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12915-020-0738-1","article-title":"The wild species genome ancestry of domestic chickens","volume":"18","author":"Lawal","year":"2020","journal-title":"BMC Biology"},{"key":"S0031182025000319_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(00)00125-2"},{"key":"S0031182025000319_ref5","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1172\/JCI74917","article-title":"Longistatin in tick saliva blocks advanced glycation end-product receptor activation","volume":"124","author":"Anisuzzaman","year":"2014","journal-title":"The Journal of Clinical Investigation."},{"key":"S0031182025000319_ref22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12639-023-01565-y","article-title":"Ex-vivo efficacy of commercially available anthelmintics against blood feeding 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Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}