{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:45:01Z","timestamp":1791852301014,"version":"4.3.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Following the recent report of strongyloidiasis caused by <jats:italic>Strongyloides fuelleborni<\/jats:italic> within a semi-captive colony of baboons in a UK safari park, we investigated the genetic relationships of this isolate with other <jats:italic>Strongyloides<\/jats:italic> isolates across the world. Whole-genome sequencing data were generated with later phylogenetic analysis of mitochondrial (mt) cytochrome oxidase subunit 1 (<jats:italic>cox1<\/jats:italic>) and nuclear ribosomal 18S sequences against 300 published <jats:italic>Strongyloides<\/jats:italic> reference genotypes. The putative African origin of the UK <jats:italic>S. fuelleborni<\/jats:italic> was confirmed and full-length mt genome sequences were assembled to facilitate a more detailed phylogenetic analysis of 14 mt coding regions against all available <jats:italic>Strongyloides<\/jats:italic> species. Our analyses demonstrated that the UK isolate represented a novel African lineage not previously described. Additional complete mt genomes were assembled for several individual UK safari park worms to reveal a slightly altered mt genome gene arrangement, allowing clear separation from Asian <jats:italic>S. fuelleborni<\/jats:italic>. Furthermore, these UK worms possessed expanded intergenic regions of unknown function that increase their mt genome size to approximately 24 kilobases (kb) as compared with some 16 kb for Asian <jats:italic>S. fuelleborni<\/jats:italic>; this may have arisen from unique populational founder and genetic drift effects set within the peculiar mixed species baboon and drill ancestry of this semi-captive primate colony. A maximum likelihood phylogeny constructed from 14 mt coding regions also supported an evolutionary distinction between Asian and African <jats:italic>S. fuelleborni<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0031182025100243","type":"journal-article","created":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T22:40:08Z","timestamp":1750632008000},"page":"735-744","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Genetic diversity within <i>Strongyloides fuelleborni<\/i>: mitochondrial genome analysis reveals a clear African and Asian division"],"prefix":"10.1017","volume":"152","author":[{"given":"Travis","family":"Richins","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-6066","authenticated-orcid":false,"given":"Sarah G. H.","family":"Sapp","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-3544","authenticated-orcid":false,"given":"Alexandra","family":"Juhasz","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine"},{"name":"Semmelweis University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3017-4074","authenticated-orcid":false,"given":"Lucas J.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-7136","authenticated-orcid":false,"given":"E. James","family":"La Course","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-3420","authenticated-orcid":false,"given":"J. Russell","family":"Stothard","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8711-2408","authenticated-orcid":false,"given":"Joel L. N.","family":"Barratt","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,6,23]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182025100243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T12:20:53Z","timestamp":1756988453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182025100243\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0031182025100243"],"URL":"https:\/\/doi.org\/10.1017\/s0031182025100243","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}