{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:55:26Z","timestamp":1762170926994,"version":"build-2065373602"},"reference-count":78,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Plasmodium simium<\/jats:italic>\n                    , a parasite of platyrrhine monkeys, is known to cause human malaria outbreaks in Southeast Brazil. It has been hypothesized that, upon the introduction of\n                    <jats:italic>Plasmodium vivax<\/jats:italic>\n                    into the Americas at the time of the European colonization, the human parasite adapted to neotropical anophelines of the\n                    <jats:italic>Kerteszia<\/jats:italic>\n                    subgenus and to local monkeys, along the Atlantic coast of Brazil, to give rise to a sister species,\n                    <jats:italic>P. simium.<\/jats:italic>\n                    Here, to obtain new insights into the origins and adaptation of\n                    <jats:italic>P. simium<\/jats:italic>\n                    to new hosts, we analysed whole-genome sequence (WGS) data from 31\n                    <jats:italic>P. simium<\/jats:italic>\n                    isolates together with a global sequence dataset of 1086\n                    <jats:italic>P. vivax<\/jats:italic>\n                    isolates. Population genomic analyses revealed that\n                    <jats:italic>P. simium<\/jats:italic>\n                    comprises a discrete parasite lineage with greatest genetic similarity to\n                    <jats:italic>P. vivax<\/jats:italic>\n                    populations from Latin America \u2013 especially those from the Amazon Basin of Brazil \u2013 and to ancient European\n                    <jats:italic>P. vivax<\/jats:italic>\n                    isolates, consistent with Brazil as the most likely birthplace of the species. We show that\n                    <jats:italic>P. simium<\/jats:italic>\n                    displays half the amount of nucleotide diversity of\n                    <jats:italic>P. vivax<\/jats:italic>\n                    from Latin America, as expected from its recent origin. We identified pairs of sympatric\n                    <jats:italic>P. simium<\/jats:italic>\n                    isolates from monkeys and from humans as closely related as meiotic half-siblings, revealing ongoing zoonotic transmission of\n                    <jats:italic>P. simium<\/jats:italic>\n                    . Most critically, we show that\n                    <jats:italic>P. simium<\/jats:italic>\n                    currently causes most, and possibly all, malarial infections usually attributed to\n                    <jats:italic>P. vivax<\/jats:italic>\n                    along the Serra do Mar Mountain Range of Southeast Brazil.\n                  <\/jats:p>","DOI":"10.1017\/s0031182025100310","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T03:17:36Z","timestamp":1752635856000},"page":"848-859","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["<i>Plasmodium simium<\/i>\n                    : birth and evolution of a zoonotic malaria parasite species"],"prefix":"10.1017","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-8026","authenticated-orcid":false,"given":"Nathalia Ramm\u00e9 M.","family":"de Albuquerque","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo"},{"name":"Institute for Genome Sciences, University of Maryland School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winni A.","family":"Ladeia","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Scalsky","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Stabler","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine"},{"name":"Swiss Tropical and Public Health Institute"},{"name":"University of Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila T.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo"},{"name":"Brazilian Center for Research in Energy and Materials"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-0690","authenticated-orcid":false,"given":"Tha\u00eds C.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo"},{"name":"School of Medical Sciences, University of Campinas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana C.","family":"Silva","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine"},{"name":"University of Maryland School of Medicine"},{"name":"NOVA University of Lisbon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo U.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo"},{"name":"NOVA University of Lisbon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"S0031182025100310_ref2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.12688\/wellcomeopenres.17795.1","article-title":"An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples","volume":"7","author":"Adam","year":"2022","journal-title":"Wellcome Open 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