{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:07:14Z","timestamp":1787062034783,"version":"build-2736575974"},"reference-count":60,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Toxoplasmosis, caused by the obligate intracellular parasite\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    , is one of the most prevalent zoonotic parasitic infections worldwide. When acquired during pregnancy,\n                    <jats:italic>T. gondii<\/jats:italic>\n                    can be transmitted to the fetus, with clinical outcomes influenced by gestational age at time of infection and the parasite\u2019s genotype. Prenatal screening enables the detection of maternal seroconversion and offers a critical window for intervention. In Uruguay, despite mandatory serological screening during pregnancy, national data on\n                    <jats:italic>T. gondii<\/jats:italic>\n                    seroprevalence and maternal seroconversion have not been updated in two decades. In addition, the genetic diversity of local strains remains poorly characterized. In this study, we analysed publicly available serological data from pregnant individuals attending Uruguay\u2019s largest public maternity hospital between 2019 and 2023. We found that seroprevalence has modestly declined from 50% (reported in 1998) to 45.5%, with a congenital transmission rate of 0.58%. Clinical analysis of affected newborns revealed chorioretinitis as the predominant manifestation. To investigate parasite diversity, we performed genotyping of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    strains using\n                    <jats:italic>in silico<\/jats:italic>\n                    PCR-RFLP following molecular detection. Our findings revealed substantial genetic diversity, including novel allele combinations not previously described in the region. These results highlight both the continued public health burden and the evolving genetic landscape of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    in Uruguay. Our findings underscore the need to strengthen surveillance and prevention strategies for congenital toxoplasmosis in South America.\n                  <\/jats:p>","DOI":"10.1017\/s0031182025100334","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T02:21:04Z","timestamp":1750645264000},"page":"860-870","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["<i>Toxoplasma gondii<\/i>\n                    seroprevalence, seroconversion rates and genetic variability in humans from Uruguay"],"prefix":"10.1017","volume":"152","author":[{"given":"Alejandra","family":"Valentin-Decuadro","sequence":"first","affiliation":[{"name":"Institut Pasteur Montevideo"},{"name":"Universidad de la Rep\u00fablica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Ramiro","family":"Tana-Hernandez","sequence":"additional","affiliation":[{"name":"Institut Pasteur 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Rossell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gimenez","sequence":"additional","affiliation":[{"name":"Centro Hospitalario Pereira Rossell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Greising","sequence":"additional","affiliation":[{"name":"Centro Hospitalario Pereira Rossell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Universidad de la Rep\u00fablica"},{"name":"Universidad de la Rep\u00fablica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Gesuele","sequence":"additional","affiliation":[{"name":"Centro Hospitalario Pereira Rossell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-9573","authenticated-orcid":false,"given":"Maria E.","family":"Francia","sequence":"additional","affiliation":[{"name":"Institut Pasteur 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Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial licence (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}