{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:06:05Z","timestamp":1785423965757,"version":"3.56.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    (\n                    <jats:italic>T. gondii<\/jats:italic>\n                    ), a zoonotic parasite, can cause severe disease in warm-blooded animals. Pathological changes in murine tissues infected with different\n                    <jats:italic>T. gondii<\/jats:italic>\n                    isolates were studied to establish factors influencing lesion severity and parasite burden. In Study A, mice were orally inoculated with genotype #3, #6 or #8 oocysts. In Study B, mice were inoculated intraperitoneally with genotype #1, #3, #6, #13, #141 or #265 tachyzoites. Mice were euthanised serially and tissues processed for histopathology. In Study A, genotype #6 caused pathology in the liver, brain, lung, intestine and kidney, predominantly associated with tachyzoites, while #8 caused mainly moderate pathology in the brain, lung and liver, usually associated with tissue pseudocysts\/cysts. Genotype #3 occasionally caused mild pathology, but the parasite was not visible in examined tissues. In Study B, genotypes #13 and #6 caused systemic infections associated with tachyzoites. Genotypes #3, #141 and #265 caused moderate pathology associated with pseudocysts\/cysts in the brain and tachyzoites in peripheral organs. Genotype #1 caused mild pathology associated with pseudocysts\/cysts in organs assessed. Comparison of genotype #6 between studies showed parasite stage and inoculation method did not affect the severity of pathology, but for #3, pathology was more severe when mice were inoculated intraperitoneally with tachyzoites compared to those inoculated orally with oocysts. This study confirmed route of infection,\n                    <jats:italic>T. gondii<\/jats:italic>\n                    strain, life stage and dose influence infection outcome and ultimately contributes to the refinement of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    pathogenesis knowledge, which is fundamental for toxoplasmosis management and treatment.\n                  <\/jats:p>","DOI":"10.1017\/s0031182026101589","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:46:22Z","timestamp":1768459582000},"page":"386-402","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Pathology and parasite distribution in mice challenged with\n                    <i>Toxoplasma gondii<\/i>\n                    from different geographical 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