{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:01:16Z","timestamp":1785427276176,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Limited data on schistosomal circulating anodic antigen (CAA) cure after praziquantel (PZQ) treatment are available from preschool-aged children (PSAC). As part of the Praziquantel In Preschool-aged children (PIP) study, we quantified CAA before and after treatment. PSAC infected with\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    were randomized to receive PZQ either as 1 dose of 40\u00a0mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    or 2 doses of 40\u00a0mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    (i.e. 80\u00a0mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) 3 hours apart at baseline, and same dose or placebo 6\u00a0months later. CAA levels were measured using the Up-Converting reporter Particle, Lateral Flow CAA assay at baseline, 4\u00a0weeks, 6\u00a0months and 12\u00a0months post baseline treatment. Cure rate (CR), as determined by CAA clearance post-treatment, and intensity reduction rate, as determined by the reduction in CAA-levels post-treatment, were calculated at the 3 time points. Multivariable logistic regression was carried out to ascertain factors associated with \u2018CAA positivity\u2019 at the 3 post-baseline treatment time points. Overall, 228\/354 PSAC enrolled had complete CAA data at all time points and were included in the analysis. The median age was 36\u00a0months (interquartile range 31\u201342). CR significantly differed at all time points with the highest CR (42.0%) at 12\u00a0months post-treatment in the group that received 80\u00a0mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    at baseline and 80\u00a0mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    at 6\u00a0months. There was no significant difference in intensity reduction rates between the 4 groups at the different time points. In conclusion, higher PZQ dosing resulted in improved schistosomal CAA cure in PSAC, and, given its established safety, supports the consideration of increasing the PZQ dose for PSAC.\n                  <\/jats:p>","DOI":"10.1017\/s0031182026102431","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:16:47Z","timestamp":1783329407000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Schistosomal circulating anodic antigen dynamics pre- and post-treatment in preschool-aged children from the PIP trial in Uganda"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0256-1859","authenticated-orcid":false,"given":"Gloria Kakoba","family":"Ayebazibwe","sequence":"first","affiliation":[{"name":"MRC\/UVRI and LSHTM Uganda Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pytsje T.","family":"Hoekstra","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-0167","authenticated-orcid":false,"given":"Andrew","family":"Edielu","sequence":"additional","affiliation":[{"name":"MRC\/UVRI and LSHTM Uganda Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Webb","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00a0jsq62","id-type":"ROR","asserted-by":"publisher"}],"name":"London School of Hygiene & Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Colt","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Brown University Warren Alpert Medical School"},{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Brown University Health Center for International Health Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-0526","authenticated-orcid":false,"given":"Paul","family":"Corstjens","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah W.","family":"Wu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Brown University Warren Alpert Medical School"},{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Brown University Health Center for International Health Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Racheal","family":"Nakyesige","sequence":"additional","affiliation":[{"name":"MRC\/UVRI and LSHTM Uganda Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin John","family":"Mugerwa","sequence":"additional","affiliation":[{"name":"MRC\/UVRI and LSHTM Uganda Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacent","family":"Nassuuna","sequence":"additional","affiliation":[{"name":"MRC\/UVRI and LSHTM Uganda Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice A.","family":"Mawa","sequence":"additional","affiliation":[{"name":"MRC\/UVRI and LSHTM Uganda Research Unit"},{"id":[{"id":"https:\/\/ror.org\/00a0jsq62","id-type":"ROR","asserted-by":"publisher"}],"name":"London School of Hygiene & Tropical Medicine"},{"id":[{"id":"https:\/\/ror.org\/04509n826","id-type":"ROR","asserted-by":"publisher"}],"name":"Uganda Virus Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govert J.","family":"Dam","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"publisher"}],"name":"Leiden University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Friedman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-4159","authenticated-orcid":false,"given":"Amaya","family":"Bustinduy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00a0jsq62","id-type":"ROR","asserted-by":"publisher"}],"name":"London School of Hygiene and Tropical Medicine Faculty of Infectious and Tropica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,6]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182026102431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:25:08Z","timestamp":1784888708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182026102431\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":0,"alternative-id":["S0031182026102431"],"URL":"https:\/\/doi.org\/10.1017\/s0031182026102431","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}