{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T18:01:09Z","timestamp":1648836069535},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>To study immunological responses in filarial infections, interleukin-2\n receptor \u03b1 (IL-2R\u03b1) expression in the peripheral blood lymphocytes\n (PBL) of Lewis rats infected with <jats:italic>Brugia pahangi<\/jats:italic> was observed\n by flow cytometry. During infection, no increase in IL-2R\u03b1 was observed\n in either microfilaraemic or amicrofilaraemic rats. The PBL of rats were\n stimulated with phytohaemagglutinin (PHA) and the frequency of IL-2R\u03b1-positivity\n was examined. After microfilariae appeared, the increase in the rate of\n IL-2R\u03b1-positivity in microfilaraemic rats was less than in amicrofilaraemic\n rats. The anergy of IL-2R\u03b1 expression in microfilaraemic rats was\n restored when their lymphocytes were cultured with normal rat serum. IL-2R\u03b1\n expression in normal uninfected rats decreased when cultured with serum\n from microfilaraemic rats. These results suggest that microfilariae-related\n factors in rat serum suppress PHA-induced IL-2R\u03b1 expression in PBL\n and thus inhibit cell proliferation and host immunity.<\/jats:p>","DOI":"10.1017\/s0031182096008049","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"65-69","source":"Crossref","is-referenced-by-count":0,"title":["Suppression of mitogen-induced IL-2R\u03b1 expression in PBL by serum\n from microfilaraemic rats chronically infected with <i>Brugia pahangi<\/i>"],"prefix":"10.1017","volume":"114","author":[{"given":"M.","family":"SATOH","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"TSUKIDATE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"EISHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"TAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"FUJITA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1997,1,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182096008049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T20:21:24Z","timestamp":1554668484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182096008049\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["S0031182096008049"],"URL":"https:\/\/doi.org\/10.1017\/s0031182096008049","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}