{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:35:38Z","timestamp":1758126938989},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:p>The time-course of differentiation\/proliferation \n\nof mast cells in gut epithelium was investigated in mice infected with\n the \n\nnematode <jats:italic>Strongyloides venezuelensis<\/jats:italic>. After infection, expression\n \n\nof proliferating cell nuclear antigen increased in gut \n\nintraepithelial mast cells on days 7 to 11, followed by an increase \n\nin the number of intraepithelial mast cells from days 11 \n\nto 14. Mast cell precursors were defined as cells that formed mast \n\ncell colonies in methylcellulose culture. After infection, \n\nthe numbers of mast cell precursors in the population of gut \n\nintraepithelial mononuclear cells (IEMNC) increased \n\nsignificantly on day 3 and returned to the pre-infection level by \n\nday 7. Mast cell precursors in Peyer's patches, mesenteric \n\nlymph nodes (MLN), and spleen also increased from day 7 p.i. \n\nProduction of IL-3 and IL-4 in MLN and spleen were \n\nincreased between 7 and 11 days p.i. These results show that \n\nmurine intestinal mastocytosis is initiated by an early increase \n\nin mast cell precursor number in the gut epithelium followed \n\nby proliferation\/differentiation of mast cells. Mast cell \n\nprecursor numbers increased even before the production of \n\nIL-3 and IL-4 in MLN and spleen, suggesting that some local \n\nfactors might be involved in this phenomenon.<\/jats:p>","DOI":"10.1017\/s0031182096008384","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"181-187","source":"Crossref","is-referenced-by-count":14,"title":["Early increase of gut intraepithelial mast cell precursors \n\nfollowing <i>Strongyloides venezuelensis<\/i> infection in mice"],"prefix":"10.1017","volume":"114","author":[{"given":"T.","family":"TEGOSHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"OKADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"NISHIDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"ARIZONO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1997,2,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182096008384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T19:09:45Z","timestamp":1557688185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182096008384\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0031182096008384"],"URL":"https:\/\/doi.org\/10.1017\/s0031182096008384","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}