{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T21:21:12Z","timestamp":1649020872697},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>We present a mathematical model which is used to interpret the\n \n\ndynamics of the immunological response of a mouse host \n\nto infection with the filarial worm <jats:italic>Onchocerca lienalis<\/jats:italic>. The \n\nmodel mimics changes in worm burden over time post-infection \n\nand after reinfection and its behaviour provides a good description of\n \n\nexperimental results. Measured production of T-cells and eosinophils \n\nis also compared with the predictions of the model. Our results show \n\nthat the immune response \n\nmechanism proposed on the basis of experimental results, involving \n\nCD4<jats:sup>+<\/jats:sup> T-cells and eosinophil destruction of the \n\nparasite, is supported by the insights gained from the mathematical \n\nmodel. Also, using the parameters estimated to describe \n\nthe primary infection dynamics, the degree of acquired immunity to \n\nsecondary infection is also well described by the \n\nmodel. Our analysis highlights the importance of obtaining \n\nquantitative measures of the many rate parameters involved \n\nin even the simplest interpretations of immunological responses to \n\nparasitic infection.<\/jats:p>","DOI":"10.1017\/s0031182096008463","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"237-243","source":"Crossref","is-referenced-by-count":1,"title":["The kinetics of immunological responses to microfilariae in \n\na murine host: experimental and mathematical studies"],"prefix":"10.1017","volume":"114","author":[{"given":"C. J.","family":"RHODES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. G.","family":"FOLKARD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"BIANCO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"ANDERSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1997,3,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182096008463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T15:19:52Z","timestamp":1554650392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182096008463\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["S0031182096008463"],"URL":"https:\/\/doi.org\/10.1017\/s0031182096008463","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}