{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:39:11Z","timestamp":1696927151558},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>Antibodies to the core region of endotoxin (endotoxin core \nantibodies, EndoCAb), which cross-react with endotoxin from \na range of Gram-negative bacteria, are maintained in relative homeostasis\n in \nhealth, but undergo marked changes in a \nnumber of different diseases associated directly or indirectly with \nendotoxaemic or septicaemic states. The levels of \nEndoCAb IgG in the blood and cerebrospinal fluid (CSF) of 35 late-stage \nsleeping sickness patients and 9 control \nindividuals were measured by ELISA. EndoCAb levels were significantly \nelevated in the patient blood (mean EndoCAb \nvalue 290 MU\/ml <jats:italic>cf<\/jats:italic>. control 182 MU\/ml, <jats:italic>P<\/jats:italic>&lt;0\u00b7001), \nand CSF (mean EndoCAb value 254 MU\/ml <jats:italic>cf<\/jats:italic>. control \n150 MU\/ml, <jats:italic>P<\/jats:italic>&lt;0\u00b7001). EndoCAb IgG levels correlated\n with \nendotoxin levels in patient blood (<jats:italic>r<\/jats:italic>=0\u00b778, \n<jats:italic>P<\/jats:italic>&lt;0\u00b7001), but \nnot in the CSF and were not reduced 6 weeks following chemotherapy, unlike \nthe endotoxin levels. It is concluded that \nlate-stage sleeping sickness is associated with chronic exposure to endotoxins \nfrom Gram-negative bacteria.<\/jats:p>","DOI":"10.1017\/s0031182096008530","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"361-365","source":"Crossref","is-referenced-by-count":11,"title":["Endotoxin antibodies in African sleeping sickness"],"prefix":"10.1017","volume":"114","author":[{"given":"V. W.","family":"PENTREATH","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"ALAFIATAYO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. R.","family":"BARCLAY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"CRAWLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"DOUA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"OPPENHEIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1997,4,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182096008530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T21:08:39Z","timestamp":1557608919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182096008530\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["S0031182096008530"],"URL":"https:\/\/doi.org\/10.1017\/s0031182096008530","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}