{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:57:36Z","timestamp":1791269856516,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>In areas where malaria is endemic, helminthic infections, caused\n by \nintestinal or filarial parasites, commonly coexist with \nmalaria in the same individual. This study investigates the course of \n<jats:italic>Plasmodium berghei<\/jats:italic> malaria infection in CBA\/J mice \ninoculated with irradiated attenuated 3rd-stage larvae (L3) of <jats:italic>Brugia \npahangi<\/jats:italic>. Peripheral eosinophil counts, serum IgE \nlevels and cytokine production revealed that the filarial antigen induced \nT-helper type 2 (Th2) cell predominance in these \nmice, which protected them against the development of cerebral malaria.\n These \nmice significantly prolonged their survival, \ncompared with the control mice after <jats:italic>P. berghei<\/jats:italic> infection. All\n of the \nmice not inoculated with irradiated L3 died within \n12 days with acute neurological manifestations unrelated to the level of \nparasitaemia after infection of <jats:italic>P. berghei<\/jats:italic>. \nConversely, most of the inoculated mice lived more than 3 weeks following \ninfection with <jats:italic>P. berghei<\/jats:italic>, dying in the fourth \nweek of severe anaemia and overwhelming parasitaemia. This suggests that \nTh2-dominant responses lead to the downregulation of susceptibility to\n murine \ncerebral malaria.<\/jats:p>","DOI":"10.1017\/s0031182096008566","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"333-338","source":"Crossref","is-referenced-by-count":52,"title":["Down-regulation of murine susceptibility to cerebral \nmalaria by inoculation with third-stage larvae of the \nfilarial nematode <i>Brugia pahangi<\/i>"],"prefix":"10.1017","volume":"114","author":[{"given":"Y.","family":"YAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"INUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"AKAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"TSUKIDATE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"FUJITA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,4,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182096008566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T21:08:39Z","timestamp":1557608919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182096008566\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["S0031182096008566"],"URL":"https:\/\/doi.org\/10.1017\/s0031182096008566","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}