{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:01:36Z","timestamp":1783195296066,"version":"3.54.6"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>This study was performed in order to define <jats:italic>Schistosoma mansoni<\/jats:italic>\n \n\nantigens that are able to function as modulator agents \n\nin the granulomatous hypersensitivity to parasite eggs in BALB\/c \n\nand C57BL\/6 mice. A fraction of <jats:italic>S. mansoni<\/jats:italic>, designated \n\nPIII, derived from adult worm antigen preparation (SWAP) was obtained using\n \n\nanion-exchange chromatography on an \n\nFPLC system. Immunization of mice with PIII in the presence of \n\n<jats:italic>Corynebacterium parvum<\/jats:italic> and Al(OH)<jats:sub>3<\/jats:sub> as adjuvant \n\ninduced an immune response in these animals as determined by ELISA and\n \n\nspleen cell proliferation assays against <jats:italic>S. \n\nmansoni<\/jats:italic> antigens SEA, SWAP and PIII. In addition, PIII caused a significant\n \n\ndegree of protection against a challenge \n\ninfection in immunized mice as observed by the decrease on worm burden\n \n\nrecovered from the portal system. We also \n\nshowed that PIII profoundly inhibited the vigorous anamnestic granulomatous\n \n\nresponse to eggs in the liver and lungs. \n\nThis suppression correlated with a significant decrease in granuloma \n\nsize. From these results we conclude that the PIII \n\npreparation contains antigens that can mediate protective anti-parasite\n \n\nimmunity and downregulate granulomatous hypersensitivity to \n\n<jats:italic>S. mansoni<\/jats:italic> eggs.<\/jats:p>","DOI":"10.1017\/s0031182097001078","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"21-28","source":"Crossref","is-referenced-by-count":58,"title":["Induction of protective immunity and modulation of \n\ngranulomatous hypersensitivity in mice using PIII, an \n\nanionic fraction of <i>Schistosoma mansoni<\/i> adult worm"],"prefix":"10.1017","volume":"115","author":[{"given":"C.","family":"HIRSCH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"ZOUAIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"ALVES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"GOES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,7,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182097001078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T20:36:15Z","timestamp":1557606975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182097001078\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["S0031182097001078"],"URL":"https:\/\/doi.org\/10.1017\/s0031182097001078","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}