{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:35Z","timestamp":1791174695480,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>The relationship between cell-mediated granulomatous inflammation\n and \ntransmission of disease in schistosomiasis and \ntuberculosis has been explored. In 2 experiments involving \n<jats:italic>Schistosoma mansoni<\/jats:italic>-infected normal and T cell-deprived \nmice, and infected deprived mice that had been variously reconstituted\n with \nimmune or normal lymphocytes or immune \nserum, there was a significant positive numerical correlation between \nmean liver granuloma diameters and faecal egg \ncounts in individual animals. Lymphocytes from donors with recently patent\n \ninfections were more active than cells from \nchronically infected or uninfected donors in reconstituting egg excretion\n \nrates in deprived recipients, and mesenteric \nlymph node (MLN) cells were more active than spleen cells. Modulation of\n \ngranulomatous activity with increasing \nchronicity of infection in the donors, resulting in a decrease in granuloma\n \nsize around freshly produced tissue-bound eggs, \nwas paralleled by a waning of the capacity of transferred lymph node cells\n \nto reconstitute egg excretion in the recipients. \nSerum taken from chronically infected donor mice over the same period and\n \ntransferred to infected deprived recipients \nbecame more active in enhancing egg excretion in the recipients as the\n \ncell-mediated activity declined. A recent study in \nKenya has found that <jats:italic>S. mansoni<\/jats:italic>-infected patients with concurrent\n \nhuman immunodefficiency virus (HIV) infection \nexcrete fewer eggs than patients exposed to the same levels of schistosome\n \ninfection, but who are not HIV-infected, thus \nindicating that schistosome egg excretion in humans is also immune-dependent.\n \nAttention is drawn to an apparently \nparallel situation in human tuberculosis, another pathogen which induces\n \na cell-mediated granulomatous immune \nresponse. Several studies have shown that patients with tuberculosis who\n \nare also HIV-seropositive tend to have fewer \ntubercle bacilli detectable in their saliva than those with tuberculosis,\n \nbut who are HIV-negative. This discrepancy, \nassociated with differences in lung pathology in HIV-positive patients,\n \nsuggests that in tuberculosis immune cell-mediated \ngranulomatous inflammation causes the destruction of host tissue in a \nmanner which facilitates onward transmission of the bacterial pathogen.<\/jats:p>","DOI":"10.1017\/s0031182097001972","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"113-125","source":"Crossref","is-referenced-by-count":31,"title":["A role for granulomatous inflammation in the transmission \nof infectious disease: schistosomiasis and tuberculosis"],"prefix":"10.1017","volume":"115","author":[{"given":"M. J.","family":"DOENHOFF","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,12,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182097001972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T15:47:49Z","timestamp":1557589669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182097001972\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["S0031182097001972"],"URL":"https:\/\/doi.org\/10.1017\/s0031182097001972","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]}}}