{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:10:49Z","timestamp":1773663049783,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:p>Schistosome cercariae of the genus \n\n<jats:italic>Trichobilharzia<\/jats:italic> are the causative agent of \n\nswimmers' itch. In order to characterize the \n\nchanges in parasites during and after the penetration of the \n\nhost skin, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> (in \n\nducks and mice) transformations of <jats:italic>T. szidati<\/jats:italic> \n\ncercariae to schistosomula were performed. Ultrastructural \n\nobservation revealed that cercariae \n\npossess a simple outer tegumental membrane with a thick \n\nglycocalyx. As with human schistosomes, the latter structure \n\ndisappears during transformation and a new double membrane \n\nwith putative protective function is formed. Our biochemical \n\nand immunological observations showed that the carbohydrate-rich \n\nglycocalyx of cercariae is readily bound by \n\nlectins and antibodies. The <jats:italic>in vitro<\/jats:italic> transformation \n\nto schistosomula can be detected by enhanced reactivity of 2 lectin \n\nprobes (PNA and ConA) with the surface. The \n\n<jats:italic>in vivo<\/jats:italic>-transformed (skin and lung) schistosomula \n\nappear to have few \n\nsurface ligands for the 12 lectin probes being tested. \n\nSimilarly, the cercarial surface and its remnants on the \n\n<jats:italic>in vitro<\/jats:italic>-produced schistosomula is recognized by sera \n\nfrom immunized mice and humans with cercarial dermatitis; \n\nthe tissue schistosomula fail to react with these antibodies. \n\nThe loss of surface targets as a part of parasite immune \n\nevasion within the host is discussed.<\/jats:p>","DOI":"10.1017\/s0031182097002059","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"139-147","source":"Crossref","is-referenced-by-count":36,"title":["Cercaria\u2013schistosomulum surface transformation of \n\n<i>Trichobilharzia szidati<\/i> and its putative immunological \n\nimpact"],"prefix":"10.1017","volume":"116","author":[{"given":"P.","family":"HOR\u00c1K","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"KOV\u00c1\u0158","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"KOL\u00c1\u0158OV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"NEBES\u00c1\u0158OV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,2,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182097002059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T19:19:22Z","timestamp":1554837562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182097002059\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["S0031182097002059"],"URL":"https:\/\/doi.org\/10.1017\/s0031182097002059","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2]]}}}