{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:13:33Z","timestamp":1791008013824,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>Chronic infection is a prominent feature of many intestinal nematode\n \ninfections in man and animals. It is also clear that \nin such situations host immunity is activated but is unable to induce a\n \nprotective response. A great deal of work has shown \nthat genetic control of host immunity contributes to the variation in worm\n \nburdens often observed in the field. There is \nincreasing appreciation, however, of the capability of infectious agents\n \nthemselves to modulate the host immune response \nand potentiate their own survival. Using an immunologically well defined\n \nmodel of intestinal nematode infection in mice \n(<jats:italic>Trichuris muris<\/jats:italic>) we have shown that parasite derived molecules\n \nshare cross reactive epitopes with the host cytokine \ninterferon-\u03b3 using cytokine specific monoclonal antibodies in ELISA,\n \nWestern blotting and immunoprecipitation assays. \nFurthermore, the parasite molecules can be shown to bind to the \ninterferon-\u03b3 receptor and induce change in lymphoid \ncells similar to those induced by murine interferon-\u03b3. The functional\n \nactivity of the molecule <jats:italic>in vivo<\/jats:italic> remains to be \ndetermined. Previous studies have established that interferon-\u03b3 is\n \ncritical for progression to chronic <jats:italic>T. muris<\/jats:italic> infection in \nmice and, therefore, it raises the distinct possibility that the production\n \nof an interferon-\u03b3 homologue by the worm may \nbe one mechanism whereby the parasite is able to interfere with the regulation\n \nof the host immune response and potentiate its own survival.<\/jats:p>","DOI":"10.1017\/s0031182097002114","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"101-105","source":"Crossref","is-referenced-by-count":57,"title":["Production of an interferon-gamma homologue by an \nintestinal nematode: functionally significant or interesting artefact?"],"prefix":"10.1017","volume":"115","author":[{"given":"R. K.","family":"GRENCIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"ENTWISTLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,12,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182097002114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T15:47:44Z","timestamp":1557589664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182097002114\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["S0031182097002114"],"URL":"https:\/\/doi.org\/10.1017\/s0031182097002114","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]}}}