{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:03:08Z","timestamp":1785564188464,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>The effects of dietary protein and zinc restrictions on \n<jats:italic>Heligmosomoides polygyrus<\/jats:italic> were compared following primary and\n \nchallenge infection in female BALB\/c mice fed either control (24%),\n \nmarginal (7%) or low (3%) protein combined with \neither high or low zinc (60 or 3 mg Zn\/kg diet). Dietary protein \nrestriction (3%) resulted in significantly lower body \nweight gain. As well, blood urea nitrogen (BUN) significantly decreased\n \nwith decreasing dietary protein level. However, \nneither plasma albumin concentration nor relative thymus or spleen \nweights were reduced. Marginal zinc deficiency was \nconfirmed by significantly lower tibia and liver zinc concentration, but\n \nfood intake, body weight gain, relative thymus and \nspleen weights, and alkaline phosphatase activity were not altered. On\n \nday 29 post-primary infection, worm burdens were \nsignificantly higher in mice fed either marginal or low protein and in\n \nmice fed a low zinc diet, while parasite egg output \nwas significantly higher in mice fed both low protein and low zinc diets.\n \nImmune status was compromised in mice fed low \nprotein (significantly lower serum IgG1 and lower eosinophilia), and in\n \nmice fed low zinc diet (significantly lower \neosinophilia). Early in the infection, IgE titres were elevated in mice\n \nfed low protein or low zinc, but IgE titres declined \nto levels lower than the control diet groups after 14\u201321 days. \nOn day 29 post-challenge infection, worm burdens and \nparasite egg output were significantly higher in mice fed low protein,\n \nwhereas the other groups had expelled almost all \nparasites. Dietary restriction had no effect on serum IgE. Significantly\n \nreduced serum IgG1 titres and eosinophilia in mice \nfed 3% protein supported the view that low dietary protein but not \nlow zinc increased host susceptibility to <jats:italic>H. polygyrus<\/jats:italic> \nby compromising host immune function following reinfection in immunized\n mice.<\/jats:p>","DOI":"10.1017\/s0031182098002431","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"449-462","source":"Crossref","is-referenced-by-count":39,"title":["Dietary protein and zinc restrictions independently modify \na <i>Heligmosomoides polygyrus<\/i> (Nematoda) infection in mice"],"prefix":"10.1017","volume":"116","author":[{"given":"M.","family":"BOULAY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"SCOTT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"CONLY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"STEVENSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. G.","family":"KOSKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1998,5,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182098002431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T15:32:30Z","timestamp":1554564750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182098002431\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["S0031182098002431"],"URL":"https:\/\/doi.org\/10.1017\/s0031182098002431","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}