{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:06:26Z","timestamp":1760169986127},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:p>Recent work has shown that mice with subclinical parasitic infections\n \nsuffer impaired spatial learning and memory, as \nassayed in an open-field water maze. Although the mechanism underlying\n \nthis effect is not clear, the phenomenon has been \nreported following infection with both a protozoan parasite \n(<jats:italic>Eimeria vermiformis<\/jats:italic>) and a gastrointestinal nematode \n(<jats:italic>Heligmosomoides polygyrus<\/jats:italic>). In a variety of experiments, we \nexamined the effects of a different gastrointestinal nematode, \n<jats:italic>Strongyloides ratti<\/jats:italic>, on the ability of rats and mice to learn\n a \nspatial or a discrimination task. Animals were tested at various \nstages post-infection, with different levels of infection, using different\n \nlines of <jats:italic>S. ratti<\/jats:italic> and with varying experimental \nprotocols. All animals learned the tasks, but we found no evidence of an\n effect \nof <jats:italic>S. ratti<\/jats:italic> infection on learning or memory. \nEven rats infected with approximately 5000 <jats:italic>S. ratti<\/jats:italic> larvae, a\n \ndose which has an impact on rat body size, showed no deficit \nin learning ability. Various reasons for the conflict between our results\n \nand those previously reported for <jats:italic>E. vermiformis<\/jats:italic> \nand <jats:italic>H. polygyrus<\/jats:italic> are discussed. Our results show that impaired\n \nlearning and memory following parasitic infection is not \na ubiquitous or at least easily replicated phenomenon.<\/jats:p>","DOI":"10.1017\/s003118209800290x","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:36:03Z","timestamp":1027762563000},"page":"145-154","source":"Crossref","is-referenced-by-count":24,"title":["Spatial and discrimination learning in rodents infected \nwith the nematode <i>Strongyloides ratti<\/i>"],"prefix":"10.1017","volume":"117","author":[{"given":"V. A.","family":"BRAITHWAITE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"SALKELD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"McADAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. G.","family":"HOCKINGS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"LUDLOW","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. F.","family":"READ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,8,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118209800290X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T15:31:59Z","timestamp":1554737519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118209800290X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["S003118209800290X"],"URL":"https:\/\/doi.org\/10.1017\/s003118209800290x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}