{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T01:59:49Z","timestamp":1750471189264},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:p>The relocation of several thousand members of the Kamba tribe from\n \nthe Kyulu Hills to the Thange valley near \nMasongaleni in Kenya provides an excellent opportunity to study the \ndevelopment of the immune response to schistosomiasis mansoni in a \npopulation with little or no previous experience \nof the infection. An adjacent, well-established \nKamba community with similar patterns of water contact provides a \nsuitable endemic control population. The immigrants \nwere, uniquely, examined shortly after their arrival in the endemic \narea, while the prevalence of infection was still low. \nAt this time faecal egg counts peaked atypically around 30 years of \nage. Over the next 12\u201318 months infection increased \nrapidly, especially among teenagers, producing a pattern of infection \nmore typical of endemic communities. This \nsubstantially narrows estimates of the time required to develop the \nimportant determinants of the age\u2013intensity profile, \nsupporting the notion that changes related to age <jats:italic>per se<\/jats:italic>, \nrather than duration of infection, dominate. Age-dependent factors \nmight include behaviour or physiology, including immune response. \nThis paper provides the background for continuing \nlongitudinal studies on the development of immunological responses to this\n parasite.<\/jats:p>","DOI":"10.1017\/s0031182098002935","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"123-132","source":"Crossref","is-referenced-by-count":21,"title":["The development of schistosomiasis mansoni in an \nimmunologically naive immigrant population in \nMasongaleni, Kenya"],"prefix":"10.1017","volume":"117","author":[{"given":"J. H.","family":"OUMA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. C.","family":"FULFORD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C.","family":"KARIUKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"KIMANI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"STURROCK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"MUCHEMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"BUTTERWORTH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W.","family":"DUNNE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,8,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182098002935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T15:32:02Z","timestamp":1554737522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182098002935\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["S0031182098002935"],"URL":"https:\/\/doi.org\/10.1017\/s0031182098002935","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}