{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:09:50Z","timestamp":1761862190745},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>A single exposure to radiation-attenuated cercariae of \n<jats:italic>Schistosoma mansoni<\/jats:italic> induces a high level of protective immunity\n in \nC57BL\/6 mice, which is mediated by Th1 responses. Events in the \nskin and\/or draining lymph nodes early after exposure \nare crucial for the induction of protection, and we have investigated \nthe interactions of vaccinating parasites with host \nleucocytes in these 2 locations. We observed extensive lateral \nspreading of cercarial secretions along layers of the stratum \ncorneum but not between keratinocytes. There was little direct contact\n \nwith host leucocytes during the first 1\u20132 days when \nthe parasites lay at the base of the epidermis, but cells accumulated \nin the underlying dermis. In contrast to normal \nparasites, attenuated larvae persisted in the dermis for &gt;10 days, \noften surrounded by aggregates of macrophages\/dendritic cells. \nWhilst cells bearing MHC II, CD11b or CD11c markers were present \nin the lymph nodes, particularly \nin the periphery and paracortical areas, no obvious redistribution \nwas seen as a result of parasite residence there for 5\u201315 \ndays. However, ultrastructural observations revealed numerous cells \nwith macrophage\/dendritic morphology in the \nvicinity of parasites, in some instances closely adherent to the \ntegument. The observations strongly suggest that the \ntegument is a potent source of the antigens which prime the immune \nsystem in the lymph nodes of vaccinated mice for a protective response.<\/jats:p>","DOI":"10.1017\/s0031182098003187","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"301-309","source":"Crossref","is-referenced-by-count":29,"title":["Induction of immunity to <i>Schistosoma mansoni<\/i>: interaction\n \nof schistosomula with accessory leucocytes in murine skin \nand draining lymph nodes"],"prefix":"10.1017","volume":"117","author":[{"given":"S.","family":"RIENGROJPITAK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"ANDERSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"WILSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,10,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182098003187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T20:07:36Z","timestamp":1557518856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182098003187\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["S0031182098003187"],"URL":"https:\/\/doi.org\/10.1017\/s0031182098003187","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}