{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:43:01Z","timestamp":1788432181817,"version":"build-2803163510"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>Tapeworms absorb and consume large quantities of glucose through\n their syncytial tegument, storing the excess as \nglycogen. Although some studies on the metabolism of glucose in several\n tapeworms are available, the proteins that mediate \nits uptake and distribution in their tissue have not been identified. We\n describe the isolation and characterization of cDNA \nclones encoding 2 facilitated diffusion glucose transporters (TGTP1 and\n TGTP2) from <jats:italic>Taenia solium<\/jats:italic>, the causal agent \nof human and porcine cysticercosis. Radio-isotope labelled hexose uptake\n mediated by TGTP1 expressed in <jats:italic>Xenopus<\/jats:italic> \noocytes is inhibited by the natural stereoisomers <jats:sc>d<\/jats:sc>-glucose and\n <jats:sc>d<\/jats:sc>-mannose but not by <jats:sc>l<\/jats:sc>-glucose. Transport by TGTP1 \nis sensitive to classical inhibitors of facilitated diffusion such as phloretin\n and cytochalasin B, and insensitive to ouabain. \nTGTP2 did not function in <jats:italic>Xenopus<\/jats:italic> oocytes. Localization studies\n using specific anti-TGTP1 and anti-TGTP2 antibodies \nshow that TGTP1 is abundant in a number of structures underlying the tegument\n in adult parasites and larvae, whereas \nTGTP2 appears to be localized only on the tegumentary surface of the larvae\n and is not detected in adults.<\/jats:p>","DOI":"10.1017\/s003118209800345x","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"579-588","source":"Crossref","is-referenced-by-count":25,"title":["Molecular and functional characterization and tissue \nlocalization of 2 glucose transporter homologues (TGTP1 \nand TGTP2) from the tapeworm <i>Taenia solium<\/i>"],"prefix":"10.1017","volume":"117","author":[{"given":"D.","family":"RODR\u00cdGUEZ-CONTRERAS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"SKELLY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"LANDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"SHOEMAKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"LACLETTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1998,12,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118209800345X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T19:48:53Z","timestamp":1557517733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118209800345X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["S003118209800345X"],"URL":"https:\/\/doi.org\/10.1017\/s003118209800345x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}