{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:07:53Z","timestamp":1761674873377},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>Both CEF6, a cation-exchange fraction of soluble <jats:italic>Schistosoma\n mansoni<\/jats:italic> egg antigens (SEA), composed of the 2 antigens, \nalpha-1 and omega-1, and haemocyanin from the keyhole limpet, <jats:italic>Megathura\n crenulata<\/jats:italic>, have shown potential for immunodiagnosis \nof human schistosomiasis. Possible cross-reactivity between antigens in\n SEA and keyhole limpet haemocyanin \n(KLH) was explored by Western immunoblotting and enzyme-linked immunosorbent\n assay (ELISA) using sera from \nrabbits immunized with KLH, SEA, CEF6, alpha-1, omega-1, or egg antigen\n k5. Both immunoassays revealed a high \ndegree of serological cross-reactivity between the schistosome egg antigens\n and KLH, much of it due to sodium periodate-\nsensitive epitopes. Cross-reactivity with schistosome antigens with proven\n diagnostic efficacy may thus, in part, explain \nthe usefulness of KLH for the diagnosis of human schistosomiasis mansoni.<\/jats:p>","DOI":"10.1017\/s0031182098003461","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"83-89","source":"Crossref","is-referenced-by-count":26,"title":["Periodate-sensitive immunological cross-reactivity between \nkeyhole limpet haemocyanin (KLH) and serodiagnostic \n<i>Schistosoma mansoni<\/i> egg antigens"],"prefix":"10.1017","volume":"118","author":[{"given":"J. V.","family":"HAMILTON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"CHIODINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"FALLON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"DOENHOFF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,1,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182098003461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T19:39:04Z","timestamp":1554752344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182098003461\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["S0031182098003461"],"URL":"https:\/\/doi.org\/10.1017\/s0031182098003461","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}