{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:55:30Z","timestamp":1758272130562},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:p>Onchocerciasis (\u2018River Blindness\u2019), caused by the filarial\n nematode <jats:italic>Onchocerca volvulus<\/jats:italic> is of major public health \nimportance in West Africa. Ivermectin, a drug originally developed for\n veterinary use, is now being incorporated in control \nstrategies but whilst it has potent efficacy against L<jats:sub>1<\/jats:sub> larvae\n (microfilariae), ivermectin is not lethal to adult (L<jats:sub>5<\/jats:sub>) <jats:italic>O.\n volvulus<\/jats:italic>, \nnor to adults of the related cattle parasite <jats:italic>O. ochengi<\/jats:italic>. We have\n exploited this model to determine if ivermectin has \nprophylactic activity against naturally transmitted, <jats:italic>O. ochengi<\/jats:italic>\n infections in a controlled, prospective study in northern \nCameroon. Calves were treated monthly with ivermectin at either 200 \u03bcg\/kg\n or 500 \u03bcg\/kg for 21 months. None of 15 \ntreated calves developed adult worm infection, whereas 5\/6 untreated\n controls became infected (<jats:italic>P<\/jats:italic>&lt;0\u00b7001) with a total \nof 54 <jats:italic>O. ochengi<\/jats:italic> nodules, and all 5 developed patent microfilaridermia.\n These results have significant implications for the \nuse of ivermectin in humans, and suggest that strategic chemotherapy at\n times of maximal transmission will confer \nprophylactic as well as therapeutic benefits.<\/jats:p>","DOI":"10.1017\/s0031182098003680","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"195-199","source":"Crossref","is-referenced-by-count":22,"title":["Chemoprophylaxis of <i>Onchocerca<\/i> infections: in a \ncontrolled, prospective study ivermectin prevents calves \nbecoming infected with <i>O. ochengi<\/i>"],"prefix":"10.1017","volume":"118","author":[{"given":"V. L.","family":"TCHAKOUT\u00c9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"BRONSVOORT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"TANYA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"RENZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"TREES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,2,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182098003680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T19:48:09Z","timestamp":1554148089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182098003680\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["S0031182098003680"],"URL":"https:\/\/doi.org\/10.1017\/s0031182098003680","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2]]}}}