{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:48:26Z","timestamp":1761216506515},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p>A recombinant cysteine protease inhibitor, onchocystatin of the\n parasitic nematode <jats:italic>Onchocerca volvulus<\/jats:italic>, was tested for its \nrole in microfilarial development in the simuliid vector. Onchocystatin\n was found to be present in female adults and skin \nmicrofilariae of the bovine parasite <jats:italic>O. ochengi<\/jats:italic>, the closest relative\n of <jats:italic>O. volvulus<\/jats:italic>. In addition the inhibitor could be detected \nas an excretory\u2013secretory (E\u2013S) product of the microfilariae.\n Co-injection of onchocystatin and the <jats:italic>O. ochengi<\/jats:italic> microfilariae\n \ninto the surrogate vector <jats:italic>Simulium ornatum<\/jats:italic> s.l. significantly\n enhanced the recovery rates of the parasite within 24 h into \nthe infection (<jats:italic>P<\/jats:italic>&gt;0\u00b7001). The findings suggest a possible\n role of onchocystatin in the evasion by the parasite of the immune \nresponse of its vector.<\/jats:p>","DOI":"10.1017\/s0031182098003795","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"305-310","source":"Crossref","is-referenced-by-count":5,"title":["Effects of an <i>Onchocerca<\/i>-derived cysteine protease \ninhibitor on microfilariae in their simuliid vector"],"prefix":"10.1017","volume":"118","author":[{"given":"S. L.","family":"KL\u00c4GER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-E.","family":"HAGEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"BRADLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,3,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182098003795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T19:18:46Z","timestamp":1554146326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182098003795\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["S0031182098003795"],"URL":"https:\/\/doi.org\/10.1017\/s0031182098003795","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}