{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:25:12Z","timestamp":1697509512740},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p>Although eosinophilic bar- or droplet-like inclusions are frequently\n detectable inside eggs deposited in the livers of \n<jats:italic>Schistosoma japonicum<\/jats:italic>-infected animals, little is known of their\n exact nature. In the livers of mice implanted with freshly \nlaid eggs, inclusion-positive eggs were found in 28\u00b77 and 46\u00b72%\n of deposited eggs at 2 and 4 weeks, respectively, after \nimplantation, but in 4\u00b73% at 5 weeks when most of the eggs had already\n degenerated. When the extent of granuloma \nformation was investigated, granulomas around inclusion-positive eggs were\n smaller than those around negative eggs. \nHost factors associated with the formation of inclusion were sought using\n <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> studies. Following the \nadministration of anti-egg antigen serum into egg-implanted mice, no increase\n in occurrence of inclusion-positive eggs \nwas seen. In a co-culture of mature eggs with infected rabbit or mouse\n serum, inclusions were rarely found. In contrast, \nthey were found in 17\u00b79% of eggs in the presence of splenic cells.\n The present study is the first to show that there is \ndecreased granuloma formation in the presence of eosinophilic inclusions\n inside eggs and our <jats:italic>in vitro<\/jats:italic> study suggests that \nhost cell\u2013egg interaction is responsible for the formation of inclusions.<\/jats:p>","DOI":"10.1017\/s0031182098003837","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"269-274","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics of eosinophilic inclusions within \n<i>Schistosoma japonicum<\/i> eggs"],"prefix":"10.1017","volume":"118","author":[{"given":"M.","family":"HIRATA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"NAKASHIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"FUKUMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,3,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182098003837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T15:18:42Z","timestamp":1554131922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182098003837\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["S0031182098003837"],"URL":"https:\/\/doi.org\/10.1017\/s0031182098003837","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}