{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:46:00Z","timestamp":1758271560584},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>The isolation of 2 genomic clones has allowed us to further characterize\n a <jats:italic>Schistosoma mansoni<\/jats:italic> serine protease designated \nSmSP1. The deduced amino acid sequence (248aa) considered as a \u2018light\n chain\u2019 encoding the active site, presents \nsignificant homologies with mouse plasma kallikrein and human factor I\n light chain. The secondary structure of SmSP1 \n\u2018light chain\u2019 is correctly predicted and may be sufficient\n by itself to constitute an active enzyme. The biological function \nof SmSP1 is unknown, however, the homology with 2 serine proteases suggests\n that SmSP1 may play a role in the evasion \nof the host immune response. This is supported by the presence of the native\n protein corresponding to SmSP1 particularly \nin schistosomula released products (SRP) and in male dorsal spines. The\n expression of this enzyme is differentially \nregulated throughout the parasite life-cycle. However, infected animals\n with <jats:italic>S. mansoni<\/jats:italic> did not produce specific antibodies \nto recombinant SmSP1. The lack of such response could be advantageous to\n the parasite by protecting itself from host \neffector mechanisms.<\/jats:p>","DOI":"10.1017\/s0031182098003874","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"389-396","source":"Crossref","is-referenced-by-count":15,"title":["Identification of a developmentally regulated <i>Schistosoma \nmansoni<\/i> serine protease homologous to mouse plasma \nkallikrein and human factor I"],"prefix":"10.1017","volume":"118","author":[{"given":"C.","family":"COCUDE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"PIERROT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"C\u00caTRE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"FONTAINE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"GODIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"CAPRON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"KHALIFE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,4,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182098003874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T20:25:42Z","timestamp":1554668742000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182098003874\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["S0031182098003874"],"URL":"https:\/\/doi.org\/10.1017\/s0031182098003874","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}