{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:56:31Z","timestamp":1697244991115},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p>Prion diseases of humans and other animals have clinical, economic and political significance. Pre-mortem diagnosis is \ntherefore of great importance. Clinical diagnostic criteria and the current status of the available diagnostic tests are \nreviewed and possible future developments discussed. Presently, most diagnostic tests are indirect, relying on findings that \nmay not be confined to prion diseases rather than on their particular intrinsic nature. They are therefore not absolutely \nspecific nor are they 100% sensitive. The electroencephalogram (EEG), cerebral imaging and cerebrospinal fluid (CSF) \nanalysis are the main techniques employed. However, there is hope that useful blood tests could be developed which would \nbe simpler and less invasive. Also, there is hope that more specific tests will become available.<\/jats:p>","DOI":"10.1017\/s0031182099004138","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:36:03Z","timestamp":1027776963000},"page":"3-11","source":"Crossref","is-referenced-by-count":5,"title":["The diagnosis of prion diseases"],"prefix":"10.1017","volume":"117","author":[{"given":"R.","family":"KNIGHT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,11,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099004138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T20:04:38Z","timestamp":1557432278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099004138\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S0031182099004138"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099004138","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}