{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:33:30Z","timestamp":1761154410295},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p>The subsets of lymphocytes and cytokines regulating the site-specific immune response in experimental cysticercosis \n(<jats:italic>Taenia crassiceps<\/jats:italic>) are not known. This study investigated the cells present at the site of infection (PECs) using flow \ncytometry and measured the cytokines produced by these cells through 50 days of infection. The results showed an \nexpansion of B220<jats:sup>+<\/jats:sup>CD5<jats:sup>+<\/jats:sup>, B220<jats:sup>+<\/jats:sup>CD5<jats:sup>\u2212<\/jats:sup>, \n\u03b1\u03b2TCR<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> cells coincident with a transient increase in IL-10 \nproduction. After the initial increase, the percentage of B220<jats:sup>+<\/jats:sup> CD5<jats:sup>\u2212<\/jats:sup> \nand helper T cells decreased with a concomitant decrease in IL-10 production. CD8<jats:sup>+<\/jats:sup> \nT cells continued to increase throughout infection and \u03b3\u03b4TCR<jats:sup>+<\/jats:sup> cells increased after \n10 days of infection. PECs demonstrated an increased IFN-\u03b3 and IL-4 production throughout infection when stimulated \nwith larval antigens. Because a Th2-type polarization has been shown for spleen cells from infected BALB\/c mice, cytokine \nprofiles of spleen cells and PECs in response to ConA and larval antigens were compared. ConA and antigen-specific \nstimulation of spleen cells from 50-day-infected mice produced increased amounts of IL-10 while PECs showed a \ndecreased IL-10 production suggesting that anatomically distinct lymphoid populations produce different cytokines and \npromote different types of responses. Surprisingly, late in infection the levels of IL-4 and IFN-\u03b3 in serum increased \nsubstantially (460-fold and 100-fold, respectively). The systemic immune response of BALB\/c mice during experimental \ncysticercosis, therefore, is a mixed Th1\/Th2-type response.<\/jats:p>","DOI":"10.1017\/s0031182099004370","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:36:03Z","timestamp":1027776963000},"page":"623-633","source":"Crossref","is-referenced-by-count":46,"title":["The systemic immune response of BALB\/c mice infected \nwith larval <i>Taenia crassiceps<\/i> is a mixed Th1\/Th2-type \nresponse"],"prefix":"10.1017","volume":"118","author":[{"given":"S. A.","family":"TOENJES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"SPOLSKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A.","family":"MOONEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"KUHN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,6,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099004370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T20:01:52Z","timestamp":1555012912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099004370\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["S0031182099004370"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099004370","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}