{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:25:03Z","timestamp":1758126303624},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>Humoral immune responses of the Indian leaf monkey (<jats:italic>Presbytis entellus<\/jats:italic>) experimentally infected with <jats:italic>Brugia malayi<\/jats:italic> and \nexhibiting disease manifestations were studied. Microfilaraemia, filaria-specific IgG and circulating immune complexes \n(CICs) were determined in the monkeys at different time-points after inoculation of <jats:italic>B. malayi<\/jats:italic> 3rd-stage larvae. Sera were \nanalysed for recognition pattern of adult parasite antigen molecules by immunoblotting. More than 60% of the infected \nmonkeys developed episodic or persistent limb oedema with or without fever and with low or no microfilaraemia. While \nboth CIC and filaria specific IgG levels were comparable in animals showing no disease symptoms (asymptomatics) and \nsome animals showing symptoms (symptomatics), IgG levels peaked during pre-patent stage in symptomatics and during \nlatent stage in asymptomatic animals. However, some of the symptomatic animals showed a low level of filaria-specific IgG \nas compared to asymptomatic and other symptomatic animals. The immunoblot analysis showed non-reactivity of 17 and \n55 kDa antigens with sera of symptomatic animals. The results thus suggest that humoral immune responses as measured \nin the present study do not precede the development of the manifestations. However, 2 non-reactive antigen molecules \nidentified by symptomatic sera need further study to establish their possible involvement, if any, in the development \nof acute disease manifestations in this model.<\/jats:p>","DOI":"10.1017\/s0031182099004394","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"53-60","source":"Crossref","is-referenced-by-count":8,"title":["Longitudinal humoral immune responses of Indian leaf \nmonkey (<i>Presbytis entellus<\/i>) to <i>Brugia malayi<\/i> infection"],"prefix":"10.1017","volume":"119","author":[{"given":"P. K.","family":"MURTHY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"TYAGI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"GHOSH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S. R.","family":"MURTHY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. K.","family":"CHATTERJEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,7,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099004394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T20:43:04Z","timestamp":1554842584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099004394\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["S0031182099004394"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099004394","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}