{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:18:59Z","timestamp":1791206339511,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p>While anaemia has long been recognized as a consequence of acute infections with malaria, the relative contributions of \ndirect erythrocyte destruction by parasites, destruction of uninfected erythrocytes and changes in erythropoiesis have been \nunclear. Fitting of parasitaemia and anaemia data from neurosyphilis patients undergoing malaria therapy to a mathematical \nmodel shows that in these patients, an average of 8\u00b75 erythrocytes were destroyed in addition to each erythrocyte \nobserved to become parasitized. The model also showed that dyserythropoiesis plays an insignificant role in the resulting \nanaemia. The anaemia occurs before a substantial antibody response to parasites or erythrocytes could be generated. We \npostulate that uninfected erythrocyte destruction occurs through phagocytosis of erythrocytes bound to merozoites killed \nas a result of the accompanying malaria paroxysms.<\/jats:p>","DOI":"10.1017\/s0031182099004564","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"127-133","source":"Crossref","is-referenced-by-count":210,"title":["Anaemia of acute malaria infections in non-immune \npatients primarily results from destruction of uninfected \nerythrocytes"],"prefix":"10.1017","volume":"119","author":[{"given":"G. N.","family":"JAKEMAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"SAUL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. L.","family":"HOGARTH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. E.","family":"COLLINS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1999,8,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099004564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T15:21:37Z","timestamp":1554650497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099004564\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["S0031182099004564"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099004564","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}