{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:11:24Z","timestamp":1758946284079},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:p>Protective immunity against larval <jats:italic>Taenia crassiceps<\/jats:italic> has been shown to rely on T cells; however, the roles of the specific \nsubsets of T cells during infection are not known. To investigate a possible role for \u03b3\u03b4T cells, this study investigated larval \ninfection in \u03b4-chain knock-out C57BL\/6 (deltaKO) and wild-type C57BL\/6 mice. It was found that deltaKO mice and \nC57BL\/6 mice were equally susceptible to infection suggesting \u03b3\u03b4T cells do not play a major role in protective immunity. \nCytokine production by concanavalin A (ConA)-stimulated spleen cells from infected deltaKO mice and C57BL\/6 mice \nwere determined. All infected mice demonstrated an increased IL-10 production suggesting a Th1-inhibitory function. \nCells from infected deltaKO mice and C57BL\/6 mice did not show increases in IL-4 production. Heavily-infected \nC57BL\/6 mice showed a decrease in IFN-\u03b3 production compared to deltaKO mice. These observations suggest that an \nincrease in IL-10 production best correlates with a non-protective immune response. To make comparisons between <jats:italic>in \nvitro<\/jats:italic> cytokine production and systemic immune responses, cytokine levels in serum were determined. C57BL\/6 mice and \ndeltaKO mice showed increases in serum levels of IL-4 and IFN-\u03b3 at 52 days post-infection. The systemic immune \nresponse of these mice, therefore, is a mixed Th1\/Th2-type response and \u03b3\u03b4T cells are apparently not responsible for \nthe systemic increases in these cytokines.<\/jats:p>","DOI":"10.1017\/s0031182099004771","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"413-418","source":"Crossref","is-referenced-by-count":7,"title":["\u03b3\u03b4T cells do not play a major role in controlling infection \nin experimental cysticercosis"],"prefix":"10.1017","volume":"119","author":[{"given":"S. A.","family":"TOENJES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"SPOLSKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A.","family":"MOONEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"KUHN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,10,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099004771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T16:11:55Z","timestamp":1557418315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099004771\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["S0031182099004771"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099004771","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10]]}}}