{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:10:53Z","timestamp":1777525853393,"version":"3.51.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:p>Ivermectin is a promising drug for the treatment of lymphatic filariasis. A meta-analysis of trials investigating the effects \nof a single treatment suggested a dose-dependent effect on the production of microfilariae (mf) by adult <jats:italic>Wuchereria \nbancrofti<\/jats:italic> parasites. A mathematical model that describes the parasite dynamics in the human host and the impact of \nivermectin treatment is presented and its outputs compared with these trials. The calculated trend in mf density after \ntreatment appears to be particularly sensitive to the assumption about the mean life-span of mf. Adopting 0.5\u20132 years \nas a range of plausible values for this mf life-span, the model is used to estimate the impact of treatment on the parasite. \nIt is found that irrespective of dosage, ivermectin eliminates 100% of the blood mf from a patient. Furthermore, at a \ndosage level of 400 \u03bcg\/kg a single treatment irreversibly reduces the mf production of the adult parasites by at least 65%. \nFor a dosage of 200 \u03bcg\/kg this reduction is at least 35%. No such effect can be concluded from the results of trials using \nlower dosages.<\/jats:p>","DOI":"10.1017\/s0031182099004783","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"385-394","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of ivermectin in the treatment of <i>Wuchereria \nbancrofti<\/i> infection: a model-based analysis of trial results"],"prefix":"10.1017","volume":"119","author":[{"given":"A. P.","family":"PLAISIER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"CAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"VAN OORTMARSSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D. F.","family":"HABBEMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,10,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099004783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T16:11:55Z","timestamp":1557418315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099004783\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["S0031182099004783"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099004783","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10]]}}}