{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:28:24Z","timestamp":1760203704438},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p>This paper reports on the influence of maternal exposure to <jats:italic>Ascaris suum<\/jats:italic> on worm burden distributions in experimentally \ninfected piglets. In the first study, sows were inoculated before and during gestation (6 months, long-term exposure) with \n10000 <jats:italic>A. suum<\/jats:italic> eggs twice weekly. In a second study, sows were inoculated during gestation only (3 months, short-term \nexposure) with increasing doses of eggs (10000\u201340000 eggs twice weekly). Helminth-naive sows served as controls in both \nstudies. The third study used the same design as the short-term exposure study, but piglets from exposed and control sows \nwere cross-suckled within 4 h of birth before colostrum uptake. All piglets were inoculated 2 or 3 times with 50 <jats:italic>A. suum<\/jats:italic> \neggs on days 4 and 7 (and 14) after birth, and left with the sows. At 10 weeks of age all piglets were necropsied, and liver \nlesions and worm burdens were recorded. Surprisingly, in piglets born to long-term exposed sows, the prevalence of <jats:italic>A. \nsuum<\/jats:italic> infection and the mean worm burden were significantly higher than those in piglets from control sows. In contrast, \nneither worm burdens nor prevalence were significantly different between piglets from short-term exposed sows compared \nwith their controls. In the cross-suckling experiment, 67% of piglets suckling control sows harboured worms at slaughter, \ncompared with 15%of piglets suckling exposed sows. Maximum likelihood analysis of worm burden distribution and the \ndegree of parasite aggregation showed 3 distinctly different types of overdispersed distributions: worm counts in piglets \nfrom control sows, in piglets from short-term exposed sows and in piglets from long-term exposed sows. When the worm \nburden data were analysed including the cross-suckled piglets by biological mother, it appeared that the control and short-term distributions converged and that only the long-term exposure was significantly different. Overall, the degree of \nparasite aggregation in piglets infected with <jats:italic>A. suum<\/jats:italic> decreased with exposure of the sows. A non-linear relationship was \nobserved between prevalence of infection and mean worm burden, which was different for piglets from exposed and \ncontrol sows, and similar to relationships of this type that previously have been found in human <jats:italic>A. lumbricoides<\/jats:italic> infections. \nIt was concluded that in porcine <jats:italic>A. suum<\/jats:italic> infections maternal exposure alters the distribution of worms in their offspring, \nin which the duration of exposure appeared to be an important influence. The results of the cross-suckling further suggest \nthat maternal factors, e.g. antibodies, are transferred via colostrum.<\/jats:p>","DOI":"10.1017\/s0031182099004916","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"509-520","source":"Crossref","is-referenced-by-count":8,"title":["Exposure of sows to <i>Ascaris suum<\/i> influences worm burden \ndistributions in experimentally infected suckling piglets"],"prefix":"10.1017","volume":"119","author":[{"given":"J.","family":"BOES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"COATES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"MEDLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"VARADY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"ERIKSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"ROEPSTORFF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"NANSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,11,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099004916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T15:58:55Z","timestamp":1557417535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099004916\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S0031182099004916"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099004916","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}