{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:49:11Z","timestamp":1758124151794},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>The free radical nitric oxide (NO) is a neuronal messenger which is synthesized from <jats:sc>L<\/jats:sc>-arginine and O<jats:sub>2<\/jats:sub> by nitric oxide \nsynthase (NOS). In the synthesis NO and <jats:sc>L<\/jats:sc>-citrulline are produced in a stoichiometric 1[ratio   ]1 relation. The activity of NOS \nwas analysed in homogenates of the rat tapeworm <jats:italic>Hymenolepis diminuta<\/jats:italic> by measuring the formation of <jats:sc>L<\/jats:sc>-[<jats:sup>3<\/jats:sup>H]citrulline \nafter incubation with <jats:sc>L<\/jats:sc>-[<jats:sup>3<\/jats:sup>H]arginine. The nature of NOS in <jats:italic>H. diminuta<\/jats:italic> was determined by studying the effect of 3 types \nof NOS inhibitors: (1) <jats:sc>L<\/jats:sc>-NAME, (2) EGTA, (3) 7-nitro-indazole. All inhibitors caused a significant but not complete \nreduction in the formation of <jats:sc>L<\/jats:sc>-[<jats:sup>3<\/jats:sup>H]citrulline. The results are discussed against the background of nerve cells and fibres \npositive for NADPH-diaphorase staining in <jats:italic>H. diminuta<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0031182099005284","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:30:22Z","timestamp":1027776622000},"page":"91-95","source":"Crossref","is-referenced-by-count":14,"title":["A radiometric analysis of nitric oxide synthase activity in \n<i>Hymenolepis diminuta<\/i>"],"prefix":"10.1017","volume":"120","author":[{"given":"N. B.","family":"TERENINA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. V.","family":"ONUFRIEV","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. V.","family":"GULYAEVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"LINDHOLM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K. S.","family":"GUSTAFSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2000,1,1]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099005284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T19:55:55Z","timestamp":1555012555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099005284\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0031182099005284"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099005284","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}