{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:33:40Z","timestamp":1791347620448,"version":"4.3.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2000,10,16]],"date-time":"2000-10-16T00:00:00Z","timestamp":971654400000},"content-version":"unspecified","delay-in-days":45,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>We describe the dynamics of co-infections of <jats:italic>Plasmodium falciparum<\/jats:italic> and <jats:italic>P. vivax<\/jats:italic> in 28 asymptomatic children by \ngenotyping these species using the polymorphic loci Msp2 and Msp3\u03b1, respectively. The total number of <jats:italic>Plasmodium<\/jats:italic> spp. \ninfections detected using 3 day sampling over 61 days varied between 1 and 14 (mean 6\u00b76). The dynamics of <jats:italic>P. falciparum<\/jats:italic> \nand <jats:italic>P. vivax<\/jats:italic> genotypes varied greatly both within and amongst children. Periodicity in the detection of <jats:italic>P. falciparum<\/jats:italic> \ninfections is consistent with the synchronous replication of individual genotypes. Replication synchrony of multiple co-\ninfecting genotypes was not detected. In 4-year-old children <jats:italic>P. falciparum<\/jats:italic> genotype complexity was reduced and episodes \nlasted significantly longer (median duration &gt; 60 days) when compared to children aged 5\u201314 years (median duration \n9 days). <jats:italic>P. vivax<\/jats:italic> genotype complexity was not correlated with age but the episode duration was also longer for this species \nin 4-year-olds than in older children but was not as long as <jats:italic>P. falciparum<\/jats:italic> episodes. Recurrence of <jats:italic>P. falciparum<\/jats:italic> and <jats:italic>P. \nvivax<\/jats:italic> genotypes over weeks was observed. We interpret these major fluctuations in the density of genotypes over time as \nthe result of the mechanism of antigenic variation thought to be present in these <jats:italic>Plasmodium<\/jats:italic> species.<\/jats:p>","DOI":"10.1017\/s0031182099006356","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"257-272","source":"Crossref","is-referenced-by-count":108,"title":["Genetic diversity and dynamics of <i>Plasmodium falciparum<\/i> and <i>P. vivax<\/i> populations in multiply infected \nchildren with asymptomatic malaria infections in Papua New Guinea"],"prefix":"10.1017","volume":"121","author":[{"given":"M. C.","family":"BRUCE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"GALINSKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"BARNWELL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"DONNELLY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"WALMSLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"ALPERS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"WALLIKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. P.","family":"DAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2000,10,16]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099006356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T15:14:51Z","timestamp":1554218091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099006356\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0031182099006356"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099006356","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}