{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:55:59Z","timestamp":1791172559218,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2000,11,9]],"date-time":"2000-11-09T00:00:00Z","timestamp":973728000000},"content-version":"unspecified","delay-in-days":39,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>The parasite, <jats:italic>Neospora caninum<\/jats:italic> is an important cause of abortion in cattle. It is transmitted vertically or horizontally and \ninfection may result in abortion or the birth of a live, healthy but infected calf at full-term. Only a proportion of infected \ncattle abort and the pathogenesis of abortion is not understood. Groups of cattle were infected with 10<jats:sup>7<\/jats:sup><jats:italic>N. caninum<\/jats:italic> \ntachyzoites intravenously at different times relative to gestation. Intravenous inoculation was chosen to reproduce the \nputative haematogenous spread of <jats:italic>N. caninum<\/jats:italic> following either recrudescence of endogenous infection or <jats:italic>de novo<\/jats:italic> infection. \nIn all cattle, infection was accompanied by high \u03b3-interferon and lymphoproliferative responses, and a biased IgG<jats:sub>2<\/jats:sub> \nresponse indicating that <jats:italic>N. caninum<\/jats:italic> infection is accompanied by a profound Th1 helper T cell-like response. Infection \nat 10 weeks gestation resulted in foetopathy and resorption of foetal tissues 3 weeks after infection in 5 out of 6 cows. \nInfection at 30 weeks gestation resulted in the birth of asymptomatic, congenitally-infected calves at full term in all 6 cows, \nwhereas the 6 cows infected before artificial insemination gave birth to live, uninfected calves. These results suggest that \nthe reason some cows abort is related to the time during gestation when they become infected or an existing infection \nrecrudesces.<\/jats:p>","DOI":"10.1017\/s0031182099006587","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:30:22Z","timestamp":1027762222000},"page":"347-358","source":"Crossref","is-referenced-by-count":173,"title":["<i>Neospora caninum<\/i>-associated abortion in cattle: \nthe time of experimentally-induced parasitaemia during \ngestation determines foetal survival"],"prefix":"10.1017","volume":"121","author":[{"given":"D. J. L.","family":"WILLIAMS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"GUY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"McGARRY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"GUY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"TASKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F.","family":"SMITH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"MacEACHERN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"CRIPPS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. F.","family":"KELLY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"TREES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2000,11,9]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182099006587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T16:15:35Z","timestamp":1557332135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182099006587\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0031182099006587"],"URL":"https:\/\/doi.org\/10.1017\/s0031182099006587","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}