{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T04:49:58Z","timestamp":1649134198422},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2001,1,2]],"date-time":"2001-01-02T00:00:00Z","timestamp":978393600000},"content-version":"unspecified","delay-in-days":62,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:p>We recently showed that, in our <jats:italic>Trichinella spiralis<\/jats:italic> rat model, first exposure, but not re-exposure to infective-stage larvae \nevoked heat shock responses in 4 test organs. Our work, however, failed to implicate either early complete clearance of \nchallenge muscle larvae (ML), or rapid elimination of newborn larvae (NBL) in the phenomenon noted in reinfected rats. \nThis study clarifies that issue using 2 established facts in <jats:italic>T. spiralis<\/jats:italic> biology and anti-<jats:italic>T. spiralis<\/jats:italic> immunology. That is, adult \nworms injure gut cells and immune destruction of NBL requires release of material also toxic to host cells. To approach \nthe above problem we analysed relevant and irrelevant rat organs for increased heat shock protein (HSP) production at \n1, 7, 14, 20 and 27 p.i. during first and second infections. Organs examined were intestines, mesenteric lymph nodes \n(MLN), heart and lungs. Using densitometric analyses of immunoblots, increased HSP expression was detected on day \n7 in intestines from both primary and secondary-infected rats albeit that the change in the latter was just short of significant. \nInterestingly, MLN only exhibited increased HSP levels in the reinfected rat model with increased HSP levels persisting \nfor 1 week. A lasting shock response was detected in reinfected rats; in contrast, first exposure resulted in shock responses \nbeing evident in lungs at either day 7 or day 14, only. These findings suggest that (i) in immune rats, a few challenge ML \ndevelop into adults, produce NBLwhich are trapped within MLN, and (ii) that anti-<jats:italic>T. spiralis<\/jats:italic> and\/or anti-NBL immunity \nis associated with an, as yet, uncomprehended stress to host's heart tissues.<\/jats:p>","DOI":"10.1017\/s003118209900671x","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:36:03Z","timestamp":1027776963000},"page":"565-573","source":"Crossref","is-referenced-by-count":1,"title":["Prior immunity to <i>Trichinella spiralis<\/i> prevents \n(re)occurrence of an explicit stress response in intestines \nbut not in mesenteric lymph nodes, heart and lungs from \nreinfected rats"],"prefix":"10.1017","volume":"121","author":[{"given":"J.","family":"P\u00c9REZ-SERRANO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"MART\u00cdNEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"REGAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. E.","family":"BERNADINA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"RODR\u00cdGUEZ-CAABEIRO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2001,1,2]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118209900671X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T20:08:14Z","timestamp":1557346094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118209900671X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["S003118209900671X"],"URL":"https:\/\/doi.org\/10.1017\/s003118209900671x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}