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One hundred and ninety patients with RDC diagnoses of major or minor depression were assessed by the Hamilton and SCL-90 symptom rating scales, the Newcastle diagnostic indices for endogenous depression and for anxiety and depression. Demographic, family and treatment response information were used as external validators.<\/jats:p><jats:p>Five pure types provided the most satisfactory solution to these data. One group corresponded to classical melancholia, occurring in older, stable, in-patients, who lacked panic-phobic symptoms. All patients with agoraphobia fell into two distinct in-patient and out-patient groups, which differed from each other in several ways. In one group, a link was found between panic attacks, agitated melancholia and familial pure depression. The second group was less symptomatic and had more atypical vegetative symptoms.<\/jats:p><jats:p>Two more groups comprised mildly symptomatic, hypochondriacal, depression, and a highly neurotic, obsessive, anxious, non-phobic depression, which was commonly related to a physical stressor.<\/jats:p>","DOI":"10.1017\/s0033291700002002","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T14:33:18Z","timestamp":1247149998000},"page":"179-189","source":"Crossref","is-referenced-by-count":26,"title":["A study of depressive typologies using grade of membership analysis"],"prefix":"10.1017","volume":"18","author":[{"given":"Jonathan","family":"Davidson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max A.","family":"Woodbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Pelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranga","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"S0033291700002002_ref017","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.129.1.15"},{"key":"S0033291700002002_ref035","first-page":"53","article-title":"Anxious depressions: clinical, family history and naturalistic outcome","volume":"6","author":"van Valkenberg","year":"1984","journal-title":"Journal of Affective Diseases"},{"key":"S0033291700002002_ref018","doi-asserted-by":"publisher","DOI":"10.3109\/00048677709159553"},{"key":"S0033291700002002_ref038","doi-asserted-by":"publisher","DOI":"10.1080\/01969727408621685"},{"key":"S0033291700002002_ref008","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290050015005"},{"key":"S0033291700002002_ref021","unstructured":"Manton K. 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