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New evidence is reviewed which suggests that \u2018classic\u2019 schizophrenia is due to a specific deficiency of prostaglandin E<jats:sub>1<\/jats:sub>while certain toxic and vitamindeficiency psychoses may be due to a broader spectrum of prostaglandin deficiency. There is also good evidence that a particular schizophrenic subgroup, which includes catatonic schizophrenia but may not be confined to it, is associated with an excess of prostaglandins. Part of the explanation may be that prostaglandin E<jats:sub>1<\/jats:sub>has a \u2018bell-shaped\u2019 dose-response curve with high concentrations having effects similar to those of prostaglandin deficiency.<\/jats:p>","DOI":"10.1017\/s0033291700006619","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T16:00:33Z","timestamp":1247155233000},"page":"43-48","source":"Crossref","is-referenced-by-count":65,"title":["Prostaglandins and schizophrenia: further discussion of the evidence"],"prefix":"10.1017","volume":"8","author":[{"given":"D. F.","family":"Horrobin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. I.","family":"Ally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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