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The patients then received treatment with<jats:sc>L<\/jats:sc>-dopa,<jats:sc>L<\/jats:sc>-dopa with carbidopa or anticholinergic drugs and\/or amantadine. During the following six-month period the subjects were assessed at intervals, both physically and psychiatrically. Forty patients were followed up for the full six-month period. The severity of physical signs and affective symptoms was shown to be significantly related at several stages of the investigation. Initially, the patients showed a high psychiatric morbidity. During treatment, 22 patients developed a depressive disorder, 12 of which had a history of previous depressive episodes. By contrast, of the 11 patients who showed very few affective symptoms during follow-up, none had a history of depression. Of the 22 patients with a depressive disorder, only two were in the anticholinergic\/amantadine group, compared with nine and 11 in the other groups.<jats:sc>L<\/jats:sc>-dopa was not an effective antidepressant agent. The probable relevance of the findings of the study to the management of patients with Parkinson's disease is outlined.<\/jats:p>","DOI":"10.1017\/s0033291700007467","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T16:10:28Z","timestamp":1247155828000},"page":"23-33","source":"Crossref","is-referenced-by-count":66,"title":["Psychiatric symptoms during<scp>L<\/scp>-dopa therapy for Parkinson's disease and their relationship to physical disability"],"prefix":"10.1017","volume":"6","author":[{"given":"R. H. S.","family":"Mindham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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