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This group had lower levels of plasma ascorbic acid and red cell folate and of urinary N-methylnicotinamide excretion relative to creatinine. Over a third of both controls and patients had evidence of thiamin deficiency, as judged by a raised percentage erythrocyte transketolase activity. An earlier finding in patients with senile dementia of reduced fasting plasma concentrations of tryptophan was confirmed for total and protein bound fractions. With the possible exception of ascorbic acid, the data could not be explained satisfactorily in terms of intake. It is suggested that the association between the phenomena of ageing, senile dementia and nutritional status merits further investigation.<\/jats:p>","DOI":"10.1017\/s0033291700009119","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T14:46:06Z","timestamp":1247150766000},"page":"297-305","source":"Crossref","is-referenced-by-count":27,"title":["Tryptophan and nutritional status of patients with senile dementia"],"prefix":"10.1017","volume":"16","author":[{"given":"D. E.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. O.","family":"Chung-A-On","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W. T.","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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