{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T04:50:31Z","timestamp":1697950231063},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:00:00Z","timestamp":1247097600000},"content-version":"unspecified","delay-in-days":8378,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:p>The age at onset of dementia of the Alzheimer, Pick or senile type in relatives of probands with early onset dementia was examined using survival analytical techniques applied to data collected by Sj\u00f6gren <jats:italic>et al.<\/jats:italic> (1952). Female relatives were found to have a higher risk of dementia than males, and there was a deficit of affected brothers compared with fathers of probands. In these comparisons due allowance was made for age at the last observation of each relative. Relatives of probable and definite Pick probands had a higher risk than relatives of probable and definite Alzheimer probands, but the difference was not significant and dementia did not occur at an earlier age to the former group.<\/jats:p><jats:p>For the relatives as a whole, and for subgroups of relatives, the risk of dementia increased with age, at least up to age 80. It is hypothesized that the pattern of the age-related hazard of dementia is due to the nature of the dementing process; that this slow degenerative process is widespread; and that individual differences in the rate of the process are under the influence of genes. The statistical methods are explained in detail as they have rarely been applied to dementia before, though Chase et al. (1983) have used life tables and survival analysis in testing genetic hypotheses, with an application to Alzheimer's disease.<\/jats:p>","DOI":"10.1017\/s0033291700010345","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T14:44:53Z","timestamp":1247150693000},"page":"583-593","source":"Crossref","is-referenced-by-count":10,"title":["Application of survival analysis to the inception of dementia"],"prefix":"10.1017","volume":"16","author":[{"given":"Elizabeth","family":"Sturt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"S0033291700010345_ref011","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780350019001"},{"key":"S0033291700010345_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(84)90029-6"},{"key":"S0033291700010345_ref007","doi-asserted-by":"publisher","DOI":"10.1038\/181651b0"},{"key":"S0033291700010345_ref002","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.512.797"},{"key":"S0033291700010345_ref008","volume-title":"Schizophrenia; The Epigenetic Puzzle","author":"Gottesman","year":"1982"},{"key":"S0033291700010345_ref017","doi-asserted-by":"publisher","DOI":"10.2307\/2528221"},{"key":"S0033291700010345_ref010","first-page":"183","volume-title":"Biological Aspects of Alzheimer's Disease","author":"Heston","year":"1983"},{"key":"S0033291700010345_ref027","first-page":"434","article-title":"Zur Korrektur des Einflusses der Lebensdauer und Todesauslese auf die Ergebnisse bestimmter Kreuzungen","volume":"11","author":"Weinberg","year":"1915","journal-title":"Archiv f\u00fcr Rassen- und Gesellschafts-Biologie"},{"key":"S0033291700010345_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(81)90026-1"},{"key":"S0033291700010345_ref023","doi-asserted-by":"publisher","DOI":"10.1007\/BF02865780"},{"key":"S0033291700010345_ref019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb26839.x"},{"key":"S0033291700010345_ref020","article-title":"Morbus Alzheimer and Morbus Pick. A genetic, clinical and pathoanatomical study","author":"Sj\u00f6gren","year":"1952","journal-title":"Acta Psychiatrica et Neurologica Scandinavica"},{"key":"S0033291700010345_ref018","doi-asserted-by":"publisher","DOI":"10.2307\/2531328"},{"key":"S0033291700010345_ref024","first-page":"1176","article-title":"Letter to the Editor","volume":"40","author":"Sturt","year":"1984","journal-title":"Biometrics"},{"key":"S0033291700010345_ref003","unstructured":"BMDP Statistical Software (1983). 1983 Printing with Additions (chief editor: Dixon W. J. ). University of California Press."},{"key":"S0033291700010345_ref009","doi-asserted-by":"publisher","DOI":"10.1159\/000117852"},{"key":"S0033291700010345_ref012","volume-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch","year":"1981"},{"key":"S0033291700010345_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1954.1"},{"key":"S0033291700010345_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700003081"},{"key":"S0033291700010345_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000005900"},{"key":"S0033291700010345_ref006","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113581"},{"key":"S0033291700010345_ref013","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"S0033291700010345_ref014","first-page":"1","article-title":"Senile dementia: a clinical, sociomedical and genetic study","volume":"39","author":"Larsson","year":"1963","journal-title":"Acta Psychiatrica Scandinavia"},{"key":"S0033291700010345_ref015","volume-title":"Alzheimer's Disease The Standard Reference","author":"Matsuyama","year":"1983"},{"key":"S0033291700010345_ref016","first-page":"3","volume-title":"The Epidemiology of Dementia","author":"Mortimer","year":"1981"},{"key":"S0033291700010345_ref021","volume-title":"The Genetics of Mental Disorders","author":"Slater","year":"1971"},{"key":"S0033291700010345_ref022","first-page":"132","volume-title":"The Epidemiology of Dementia","author":"Sluss","year":"1981"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291700010345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T04:53:23Z","timestamp":1558500803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291700010345\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["S0033291700010345"],"URL":"https:\/\/doi.org\/10.1017\/s0033291700010345","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}