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Significantly more patients in each group than controls showed abnormal activation of transketolase, not only by 0\u00b73 mM thiamin diphosphate (TDP) but also in further activation by increase to 3 mM. This indicated the presence in a proportion of the alcoholic and the demented patients of an abnormal enzyme variant, similar to that previously found <jats:italic>in vitro<\/jats:italic>. The modified transketolase activation test may warn not only of marginal thiamin deficiency but also independently, of susceptibility to brain damage in patients at risk.<\/jats:p>","DOI":"10.1017\/s0033291700024843","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T14:37:15Z","timestamp":1247150235000},"page":"311-318","source":"Crossref","is-referenced-by-count":24,"title":["The activation of red blood cell transketolase in groups of patients especially at risk from thiamin deficiency"],"prefix":"10.1017","volume":"17","author":[{"given":"Marina D.","family":"Jeyasingham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver E.","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George 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