{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:05:42Z","timestamp":1759133142524},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:00:00Z","timestamp":1247097600000},"content-version":"unspecified","delay-in-days":5821,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:p>One hundred and six HIV-positive drug users were tested with a two-tone auditory evoked potential (AEP) task and a small battery of neuropsychological tests, to examine the relationship between the latency of the P300 component (P3) of the AEP, intellectual function, mood and drug use. Principal components analysis revealed a significant correlation between P3 latency and the first principal component (<jats:italic>r<\/jats:italic> = \u22120\u00b743, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001). Varimax rotation generated three orthogonal components which we interpreted as intellectual performance, memory, and mood. Intellectual performance and self-reported mood were individually correlated with P3 latency, but memory was not (<jats:italic>r<\/jats:italic> = \u22120\u00b736, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001; <jats:italic>r<\/jats:italic> = 0\u00b723, <jats:italic>P<\/jats:italic> &lt; 0\u00b705; and <jats:italic>r<\/jats:italic> = \u22120\u00b718, NS, respectively).<\/jats:p><jats:p>Subjects with symptomatic HIV disease had a higher correlation between P3 latency and intellectual performance than subjects with asymptomatic HIV disease and, among patients with symptomatic HIV disease, poorer memory was associated with a lower CD4 count. Opiate or benzodiazepine consumption did not correlate with poor intellectual performance, memory, or selfrated mood in our sample. These results indicate that there is a relationship between AEP latency and neuropsychological measures of intellectual function, and that it is influenced by subjective mood. Surprisingly, declared current drug use has no discriminable effect on these relationships.<\/jats:p>","DOI":"10.1017\/s0033291700025393","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T10:04:08Z","timestamp":1247133848000},"page":"613-622","source":"Crossref","is-referenced-by-count":16,"title":["The Edinburgh cohort of HIV-positive drug users: the relationship between auditory P3 latency, cognitive function and self-rated mood"],"prefix":"10.1017","volume":"23","author":[{"given":"V. G.","family":"Egan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chiswick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Brettle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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