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Plasma melatonin concentrations were measured throughout the night at 0, 1, 7 and 21 days and were higher during treatment with (+)oxaprotiline than with (\u2212)oxaprotiline for the entire three weeks of treatment. Since NA stimulates the production and secretion of melatonin, these results are consistent with a sustained increase in noradrenergic activity within the pineal, during 21 days of treatment with an effective NA uptake inhibitor.<\/jats:p>","DOI":"10.1017\/s0033291700032736","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T14:12:49Z","timestamp":1247148769000},"page":"61-67","source":"Crossref","is-referenced-by-count":13,"title":["The acute and chronic effects of (+) and (\u2212) oxaprotiline upon melatonin secretion in normal subjects"],"prefix":"10.1017","volume":"22","author":[{"given":"E.","family":"Palazidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Skene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Arendt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Everitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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