{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:36:58Z","timestamp":1789990618957,"version":"4.0.1"},"reference-count":57,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:00:00Z","timestamp":1247097600000},"content-version":"unspecified","delay-in-days":4999,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:p>Diffuse loss of cortical volume and ventricular enlargement have been demonstrated in schizophrenia using imaging. In addition, histological studies have provided evidence that the number of neurons in the medial temporal lobe structures is reduced and that the cytoarchitecture is abnormal. In an attempt to correlate these histological findings with <jats:italic>in vivo<\/jats:italic> estimates of neuronal integrity we have studied the concentration of the neuronal marker N-acetyl aspartate (NAA) in the hippocampi of schizophrenics using <jats:italic>in vivo<\/jats:italic> Magnetic Resonance Spectroscopy (MRS). Compared with a group of healthy volunteers schizophrenics showed a 22% loss of NAA in the left hippocampus. Two other metabolites, choline and creatine showed bilateral reduction in schizophrenics and these achieved significance in the left hippocampus. These results indicate a significant depletion of NAA in schizophrenia and are in close agreement with the reported neuronal loss in the hippocampus detected histologically. We propose that <jats:italic>in vivo<\/jats:italic> MRS is a valid measure of integrity of neuronal populations in schizophrenia.<\/jats:p>","DOI":"10.1017\/s0033291700033171","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T13:40:44Z","timestamp":1247146844000},"page":"1201-1209","source":"Crossref","is-referenced-by-count":81,"title":["Proton magnetic resonance spectroscopy: an <i>in vivo<\/i> method of estimating hippocampal neuronal depletion in schizophrenia"],"prefix":"10.1017","volume":"25","author":[{"given":"M.","family":"Maier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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