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The endogenous group's unipolar and bipolar subgroups had significantly different platelet MAO activity, respectively high and low. The differences in MAO activity between unipolar and bipolar patients appeared to persist in the well state, but not after lithium carbonate therapy. These differences in MAO activity were apparent with the substrate tyramine but not with benzylamine. Altered MAO activity in patients with affective disorders may be determined through genetic mechanisms.<\/jats:p>","DOI":"10.1017\/s0033291700034048","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T15:45:43Z","timestamp":1247154343000},"page":"729-736","source":"Crossref","is-referenced-by-count":72,"title":["Altered platelet monoamine oxidase activity in affective disorders"],"prefix":"10.1017","volume":"9","author":[{"given":"John","family":"Mann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"S0033291700034048_ref031","doi-asserted-by":"publisher","DOI":"10.1007\/BF01249439"},{"key":"S0033291700034048_ref030","first-page":"37","article-title":"Monoamine oxidase its blood platelets from manic and depressed patients","volume":"31","author":"Takahashi","year":"1977","journal-title":"Folia Psychiatrica et Neurologica Japonica"},{"key":"S0033291700034048_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90370-1"},{"key":"S0033291700034048_ref027","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.122.5.509"},{"key":"S0033291700034048_ref023","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"S0033291700034048_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(76)90031-4"},{"key":"S0033291700034048_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(69)90047-2"},{"key":"S0033291700034048_ref017","first-page":"341","volume-title":"Monoamine Oxidase and Its Inhibition","author":"Murphy","year":"1976"},{"key":"S0033291700034048_ref016","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folinphenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"S0033291700034048_ref015","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1977.01770170111011"},{"key":"S0033291700034048_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(75)90053-8"},{"key":"S0033291700034048_ref010","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"S0033291700034048_ref009","unstructured":"Gurney C. 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