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We studied the effect of moderate dieting in healthy women on the prolactin response to the serotonin (5-HT) receptor agonist, m-chlorophenylpiperazine (mCPP), a measure of the sensitivity of post-synaptic 5-HT<jats:sub>2C<\/jats:sub>receptors. Dieting significantly increased the prolactin response to mCPP and lowered plasma concentrations of the 5-HT precursor, tryptophan. We propose that dieting in women is associated with the development of functional supersensitivity of 5-HT<jats:sub>2C<\/jats:sub>receptors, probably in response to lowered levels of brain 5-HT. Alterations in brain 5-HT neurotransmission could play a part in dieting-induced dysregulation of eating and the development of clinical eating disorders in predisposed individuals.<\/jats:p>","DOI":"10.1017\/s003329170003587x","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T13:33:30Z","timestamp":1247146410000},"page":"1155-1159","source":"Crossref","is-referenced-by-count":55,"title":["Moderate dieting causes 5-HT<sub>2C<\/sub>receptor supersensitivity"],"prefix":"10.1017","volume":"26","author":[{"given":"P. J.","family":"Cowen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E. 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