{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:18:13Z","timestamp":1758817093443},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:00:00Z","timestamp":1247097600000},"content-version":"unspecified","delay-in-days":10661,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1980,5]]},"abstract":"<jats:title>SYNOPSIS<\/jats:title><jats:p>Two hundred and forty neurotic out-patients were allocated to no diagnostic category but were rated in terms of observer and self ratings of both depression and anxiety at weekly intervals during a 4-week trial of amitriptyline, diazepam, amitriptyline and diazepam, and placebo. The sample could not be divided into anxious and depressed groups on the basis of the clinical picture. The outcome tended to be good irrespective of medication but the significant drug effects found were due to amitriptyline and concerned measures of anxiety as well as depression. It is concluded that a distinction between anxiety and depression in neurotic out-patients is of no practical value with regard to drug treatment.<\/jats:p>","DOI":"10.1017\/s0033291700044081","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T15:41:03Z","timestamp":1247154063000},"page":"321-328","source":"Crossref","is-referenced-by-count":171,"title":["Neurotic illness and its response to anxiolytic and antidepressant treatment"],"prefix":"10.1017","volume":"10","author":[{"given":"Eve C.","family":"Johnstone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G. Cunningham","family":"Owens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Frith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klim","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Dowie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Riley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviva","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"S0033291700044081_ref006","volume-title":"Some Observations on the Natural History of Neurotic Illness","author":"Greer","year":"1966"},{"key":"S0033291700044081_ref027","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.128.2.156"},{"key":"S0033291700044081_ref023","first-page":"468","article-title":"Differential drug effects in neurotic depression","volume":"31","author":"Rickels","year":"1970","journal-title":"Diseases of the Nervous System"},{"key":"S0033291700044081_ref022","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1974.01760090020004"},{"key":"S0033291700044081_ref017","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1972.01750290063012"},{"key":"S0033291700044081_ref015","first-page":"30","volume-title":"Inquiries in Psychiatry, Clinical and Social Investigations","author":"Lewis","year":"1967"},{"key":"S0033291700044081_ref010","first-page":"67","volume-title":"The Role of Diagnosis in Psychiatry","author":"Kendell","year":"1975"},{"key":"S0033291700044081_ref012","volume-title":"Physiological Measures, Sedative Drugs and Morbid Anxiety","author":"Lader","year":"1966"},{"key":"S0033291700044081_ref003","first-page":"18","article-title":"A standardised psychiatric interview for use in community surveys","volume":"24","author":"Goldberg","year":"1970","journal-title":"British Journal of Preventive and Social Medicine"},{"key":"S0033291700044081_ref025","first-page":"162","volume-title":"Clinical Psychopharmacology","author":"Shepherd","year":"1968"},{"key":"S0033291700044081_ref021","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1976.220"},{"key":"S0033291700044081_ref014","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.4.306"},{"key":"S0033291700044081_ref004","volume-title":"Benzodiazepines in Clinical Practice","author":"Greenblatt","year":"1974"},{"key":"S0033291700044081_ref024","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.121.2.147"},{"key":"S0033291700044081_ref019","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.120.555.147"},{"key":"S0033291700044081_ref005","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-196306000-00004"},{"key":"S0033291700044081_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700045827"},{"key":"S0033291700044081_ref009","first-page":"655","article-title":"Comparison of major drug therapies for alleviation of anxiety and depression","volume":"32","author":"Henry","year":"1971","journal-title":"Diseases of the Nervous System"},{"key":"S0033291700044081_ref001","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.111.477.659"},{"key":"S0033291700044081_ref016","first-page":"872","article-title":"Discussion on manic-depressive psychosis","volume":"ii","author":"Mapother","year":"1926","journal-title":"British Medical Journal"},{"key":"S0033291700044081_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1967.tb00530.x"},{"key":"S0033291700044081_ref030","volume-title":"Manual of the International Statistical Classification of Diseases, Injuries and Causes of Death","volume":"1","year":"1977"},{"key":"S0033291700044081_ref026","first-page":"81","volume-title":"Clinical Psychiatry","author":"Slater","year":"1969"},{"key":"S0033291700044081_ref028","volume-title":"STAI - Manual for the State-Trait Anxiety Inventory","author":"Spielberger","year":"1970"},{"key":"S0033291700044081_ref018","volume-title":"Generalised Linear Models","author":"Nelder","year":"1975"},{"key":"S0033291700044081_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/BF02193476"},{"key":"S0033291700044081_ref029","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-196208000-00006"},{"key":"S0033291700044081_ref020","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1969.01740240113014"},{"key":"S0033291700044081_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92660-0"},{"key":"S0033291700044081_ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291700044081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T19:20:15Z","timestamp":1558898415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291700044081\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,5]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,5]]}},"alternative-id":["S0033291700044081"],"URL":"https:\/\/doi.org\/10.1017\/s0033291700044081","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,5]]}}}