{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:02:30Z","timestamp":1761058950002},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:00:00Z","timestamp":1247097600000},"content-version":"unspecified","delay-in-days":12669,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:title>SYSNOPSIS<\/jats:title><jats:p>Twenty outpatients suffering from chronic anxiety states completed a trial of anxiolytic drug therapy. They each received five treatments: amylobarbitone sodium, chlordiazepoxide, diazepam, medazepam, and a placebo in flexible dosage in a fully balanced design, using doubleblind procedures. They were assessed on the Hamilton rating scale for anxiety after a period of two to four weeks on each of the treatments and they completed self-ratings every three days. The selfratings were composed of at least three prime symptoms chosen by the patient himself and phrased in his own words as well as \u2018loss of appetite\u2019 and \u2018insomnia\u2019. Neither placebo nor amylobarbitone produced any substantial improvement from pre-drug levels of anxiety but all three benzodiazepines produced significant and very similar decreases in both Hamilton ratings and self-ratings. These two measures also correlated highly. The majority of the patients continued with medazepam at the end of the formal trial.<\/jats:p>","DOI":"10.1017\/s0033291700045827","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T16:18:56Z","timestamp":1247156336000},"page":"381-387","source":"Crossref","is-referenced-by-count":28,"title":["Clinical comparison of anxiolytic drug therapy"],"prefix":"10.1017","volume":"4","author":[{"given":"Malcolm H.","family":"Lader","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyson J.","family":"Bond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Colin","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"S0033291700045827_ref010","first-page":"149","article-title":"Experimental designs balanced for the estimation of residual effects of treatments","volume":"2","author":"Williams","year":"1949","journal-title":"Australian Journal of Scientific Research"},{"key":"S0033291700045827_ref006","volume-title":"Physiological Measures, Sedative Drugs and Morbid Anxiety","author":"Lader","year":"1966"},{"key":"S0033291700045827_ref009","first-page":"172","article-title":"The controlled evaluation of a new tranquillizing drug medazepam in the treatment of anxiety","volume":"25","author":"Silverstone","year":"1971","journal-title":"British Journal of Clinical Practice"},{"key":"S0033291700045827_ref008","first-page":"29","article-title":"Estudio de un doble \u201ctest\u201d ciego con \u2018Nobrium\u2019","volume":"4","author":"Perez Lopez","year":"1970","journal-title":"Ciencias Neurologicas"},{"key":"S0033291700045827_ref007","first-page":"726","article-title":"Studio in doppio-cieco sull'impiego del Nobrium in terapia ambulatoriale","volume":"94","author":"Pasini","year":"1970","journal-title":"Rivista Sperimentale di Freniatria e Medicina Legale delle Alienazioni Mentali"},{"key":"S0033291700045827_ref001","doi-asserted-by":"crossref","unstructured":"Bond A. J. , James D. C. , and Lader M. H. (1974a). Physiological and psychological measures in anxious patients. Psychological Medicine (In press).","DOI":"10.1017\/S0033291700045815"},{"key":"S0033291700045827_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700045815"},{"key":"S0033291700045827_ref005","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5741.151"},{"key":"S0033291700045827_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(69)71706-6"},{"key":"S0033291700045827_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"S0033291700045827_ref011","doi-asserted-by":"publisher","DOI":"10.1037\/11774-000"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291700045827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T20:51:38Z","timestamp":1559163098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291700045827\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,11]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1974,11]]}},"alternative-id":["S0033291700045827"],"URL":"https:\/\/doi.org\/10.1017\/s0033291700045827","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,11]]}}}