{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:50:11Z","timestamp":1791078611758,"version":"4.1.0"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:00:00Z","timestamp":1247097600000},"content-version":"unspecified","delay-in-days":9655,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:p>The rate of occurrence of conduct disorder and affective illness was studied for a sample of 112 offspring of 34 Huntington's Disease (HD) patients. Psychiatric disorder in the offspring was assessed as a function of: (1) age of the parent at the onset of symptoms of HD; (2) family disorganization; and (3) psychiatric disorder in either parent. The findings indicated an increased frequency of conduct disorder in disrupted families, most especially in those where the HD parent had an early onset of symptoms and the non-HD parent showed psychiatric disorder. Affective disorder in the offspring was most strongly associated with the presence of similar symptoms in the HD parent. Affective disorder, but not conduct disorder, may be an early manifestation of the HD gene. The implication of these findings for genetic counselling is discussed.<\/jats:p>","DOI":"10.1017\/s0033291700050054","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T11:16:08Z","timestamp":1247138168000},"page":"45-52","source":"Crossref","is-referenced-by-count":100,"title":["Conduct disorder and affective disorder among the offspring of patients with Huntington's Disease"],"prefix":"10.1017","volume":"13","author":[{"given":"Susan E.","family":"Folstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Lousie","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Chase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshal F.","family":"Folstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"S0033291700050054_ref004","first-page":"221","article-title":"Personality disorder in Huntington's Disease","volume":"3","author":"Dewhurst","year":"1970","journal-title":"Psychiatric Clinics"},{"key":"S0033291700050054_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700047966"},{"key":"S0033291700050054_ref016","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.126.6.520"},{"key":"S0033291700050054_ref011","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.84.348.21"},{"key":"S0033291700050054_ref010","first-page":"320","article-title":"On chorea","volume":"26","author":"Huntington","year":"1872","journal-title":"Medical and Surgical Reporter"},{"key":"S0033291700050054_ref008","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198004000-00003"},{"key":"S0033291700050054_ref015","volume-title":"Cycles of Disadvantage","author":"Rutter","year":"1976"},{"key":"S0033291700050054_ref017","unstructured":"Thompson W. D. , Orvaschel H. , Prusoff B. A. & Kidd K. K. (1983). An evaluation of the family history method for ascertaining psychiatric disorders. Archives of General Psychiatry (In the press)."},{"key":"S0033291700050054_ref005","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.116.532.255"},{"key":"S0033291700050054_ref002","first-page":"298","article-title":"Huntington's Chorea: historical, clinical and laboratory synopsis","volume":"6","author":"Bruyn","year":"1968","journal-title":"Handbook of Clinical Neurology"},{"key":"S0033291700050054_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1980.tb00586.x"},{"key":"S0033291700050054_ref003","first-page":"319","volume-title":"Genetic Research Strategies in Psychobiology and Psychiatry","author":"Cloninger","year":"1981"},{"key":"S0033291700050054_ref006","first-page":"76A","article-title":"Huntington's Disease: association with major affective disorder","volume":"33","author":"Folstein","year":"1981","journal-title":"Journal of Human Genetics"},{"key":"S0033291700050054_ref009","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.112.489.819"},{"key":"S0033291700050054_ref012","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.116.532.241"},{"key":"S0033291700050054_ref014","volume-title":"Deviant Children Grown Up","author":"Robins","year":"1966"},{"key":"S0033291700050054_ref013","first-page":"201","article-title":"Huntington's Chorea in Michigan. I. Demography and genetics","volume":"10","author":"Reed","year":"1958","journal-title":"American Journal of Human Genetics"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291700050054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T15:41:47Z","timestamp":1558712507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291700050054\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["S0033291700050054"],"URL":"https:\/\/doi.org\/10.1017\/s0033291700050054","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}